The effect of pinealectomy and leptin hormone on the proliferation and apoptosis activation in Syrian hamster testis in different photoperiods

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dc.authorid0000-0002-1197-2468
dc.contributor.authorGündüz, Bülent
dc.contributor.authorKarakaş, Alper
dc.contributor.authorTerzi, Hakan
dc.contributor.authorÖner, Jale
dc.contributor.authorSerin, Erdinç
dc.contributor.authorKükner, Aysel
dc.date.accessioned2021-06-23T19:26:09Z
dc.date.available2021-06-23T19:26:09Z
dc.date.issued2009
dc.departmentBAİBÜ, Fen Edebiyat Fakültesi, Biyoloji Bölümüen_US
dc.description.abstractP>The effects of pinealectomy and leptin hormone on proliferative and apoptotic processes in the epithelia of testicular seminiferous tubules of Syrian hamsters have been investigated. Proliferative and apoptotic processes were assessed semi-quantitatively by proliferating cell nuclear antigen (PCNA) and caspase-3 immune stainings. Animals used in the study were divided into four groups; control, pinealectomy (PinX), leptin-treated (10 mu g/mL/day/kg body weight, intraperitoneally) and pinealectomy + leptin groups. Half of the hamsters in each group were exposed to short and the other half to long photoperiods for 8 weeks. In short photoperiod, PCNA activity especially in spermatogonia was significantly higher in the pinealectomy and leptin-treated groups compared with the control group. Histological score (HSCORE) value of PCNA in the PinX + leptin group was lower than those of PinX and leptin-treated groups. HSCORE value of caspase-3 in PinX and PinX + leptin groups was increased. In the long photoperiod, PCNA activation in the PinX group was significantly lower than the control group while the differences between the controls and other groups were not significant. The difference between the increases in caspase-3 activity in the PinX and control groups was significant. Thus, it was observed that photoperiods had no effect on the proliferation activity in the control groups. The inhibiting effect of short photoperiod on testis was not observed throughout 8 weeks. PinX eliminated the inhibiting effect of short photoperiod but did not alter the stimulating effect of long photoperiod. Leptin did not show any effect in long photoperiod but decreased proliferation by stimulating melatonin in short photoperiod.en_US
dc.identifier.doi10.1111/j.1365-2605.2008.00867.x
dc.identifier.endpage352en_US
dc.identifier.issn0105-6263
dc.identifier.issue4en_US
dc.identifier.pmid18248398en_US
dc.identifier.scopus2-s2.0-67651253100en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage343en_US
dc.identifier.urihttps://doi.org/10.1111/j.1365-2605.2008.00867.x
dc.identifier.urihttps://hdl.handle.net/20.500.12491/6438
dc.identifier.volume32en_US
dc.identifier.wosWOS:000267831600008en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorGündüz, Bülent
dc.institutionauthorKarakaş, Alper
dc.institutionauthorTerzi, Hakan
dc.institutionauthorSerin, Erdinç
dc.institutionauthorKükner, Aysel
dc.language.isoenen_US
dc.publisherWiley-Blackwell Publishing, Incen_US
dc.relation.ispartofInternational Journal Of Andrologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCaspase-3en_US
dc.subjectLeptinen_US
dc.subjectPhotoperioden_US
dc.subjectPinealectomyen_US
dc.subjectProliferating Cell Nuclear Antigenen_US
dc.subjectTestisen_US
dc.titleThe effect of pinealectomy and leptin hormone on the proliferation and apoptosis activation in Syrian hamster testis in different photoperiodsen_US
dc.typeArticleen_US

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