Hypobaric-hypoxia-induced pulmonary damage in rats ameliorated by antioxidant erdosteine

Basit Öğe Kaydı
dc.authorid0000-0002-8352-6571en_US
dc.authorid0000-0002-7413-1367en_US
dc.authorid0000-0002-7661-8830en_US
dc.authorid0000-0002-2319-1757en_US
dc.authorid0000-0003-1380-350X
dc.authorid0000-0003-1937-9244
dc.contributor.authorUzun, Özge
dc.contributor.authorBalbay, Öner
dc.contributor.authorÇomunoğlu, Nil Üstündağ
dc.contributor.authorYavuz, Özlem
dc.contributor.authorAnnakkaya, Ali Nihat
dc.contributor.authorGüler, Selver
dc.contributor.authorSılan, Coşkun
dc.date.accessioned2021-06-23T19:19:28Z
dc.date.available2021-06-23T19:19:28Z
dc.date.issued2006
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractFree radical-mediated injury to lung and pulmonary vasculature is an important mechanism in hypoxia-induced lung damage. In this study, we aimed to investigate the potential protective effects of erdosteine as an antioxidant agent on hypobaric hypoxia-induced pulmonary hypertension. Adult mate rats were assigned randomly to three groups. The first group of rats was exposed to hypobaric-hypoxia and the second group was treated with erdosteine (20 mg/kg, daily) for 2 weeks, during which time they were in a hypoxic chamber. These groups were compared with normoxic controls. All. rats were sacrificed after 2 weeks. The hypoxia-induced increase in right ventricle to left ventricle plus septum weight ratio (from 0.20+/-0.01 to 0.26+/-0.01) was reduced significantly in the erdosteine-treated group (0.23+/-0.01). Malondialdehyde levels were elevated (from 0.33+/-0.11 to 0.59+/-0.02) and total antioxidant status was not changed significantly (from 1.77+/-0.42 to 2.61+/-0.23) by hypoxia. In contrast to the hypoxia-exposed group, malondialdehyde levels were significantly decreased in the erdosteine-treated group (0.37+/-0.02). Total antioxidant status (4.03+/-0.22) was significantly higher in erdosteine-treated rats when compared to non-treated rats. Histopathotogical examination demonstrated that erdosteine prevented inflammation and protected lung parenchyma and pulmonary endothelium of hypoxia-exposed rats.en_US
dc.identifier.doi10.1016/j.acthis.2006.01.001
dc.identifier.endpage68en_US
dc.identifier.issn0065-1281
dc.identifier.issn1618-0372
dc.identifier.issue1en_US
dc.identifier.pmid16537087en_US
dc.identifier.scopus2-s2.0-33745499904en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage59en_US
dc.identifier.urihttps://doi.org/10.1016/j.acthis.2006.01.001
dc.identifier.urihttps://hdl.handle.net/20.500.12491/5945
dc.identifier.volume108en_US
dc.identifier.wosWOS:000237919500007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorUzun, Özge
dc.institutionauthorBalbay, Öner
dc.institutionauthorYavuz, Özlem
dc.institutionauthorAnnakkaya, Ali Nihat
dc.institutionauthorSılan, Coşkun
dc.language.isoenen_US
dc.publisherElsevier Gmbh, Urban & Fischer Verlagen_US
dc.relation.ispartofActa Histochemicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectErdosteineen_US
dc.subjectPulmonary Hypertensionen_US
dc.subjectFree Radicalsen_US
dc.subjectLungen_US
dc.subjectEndotheliumen_US
dc.titleHypobaric-hypoxia-induced pulmonary damage in rats ameliorated by antioxidant erdosteineen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
ozge-uzun.pdf
Boyut:
1.05 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam metin/ Full text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Dahili Tıp Bilimleri Bölümü Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
Temel Tıp Bilimleri Bölümü Koleksiyonu