Subclinical immune reactions to viral infections may correlate with child and adolescent diagnosis of attention-deficit/hyperactivity disorder: a preliminary study from Turkey

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dc.authorid0000-0001-6133-9604en_US
dc.authorid0000-0002-5643-3038en_US
dc.authorid0000-0001-5207-6240en_US
dc.authorid0000-0003-2469-9509en_US
dc.contributor.authorBekdaş, Mervan
dc.contributor.authorTufan, Ali Evren
dc.contributor.authorHakyemez, İsmail Necati
dc.contributor.authorTaş, Tekin
dc.contributor.authorAltunhan, Hüseyin
dc.contributor.authorDemircioğlu, Fatih
dc.contributor.authorKısmet, Erol
dc.date.accessioned2021-06-23T19:36:40Z
dc.date.available2021-06-23T19:36:40Z
dc.date.issued2014
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground: Attention-Deficit/Hyperactivity Disorder (ADHD) is one of the most common neuro-developmental disorders of childhood and adolescence. Studies focusing on the relationship of infectious agents and ADHD are scarce. It is also known that cerebellar injury may lead to hyperactive behavior. This study aimed to evaluate the relationship between viral agents of cerebellitis and the diagnosis of ADHD. Methods: The study group was formed of 60 consecutive ADHD patients and 30 healthy children. IgG levels for VZV; HSV-1, CMV, Measles, Mumps, Rubella and EBV were evaluated. Results: Males were significantly higher among patients with ADHD (65% vs. 40%, p=0.025). Patients with ADHD displayed significantly higher positivity for measles IgG (80% vs. 60%, p=0.044). When patients with ADHD were classified according to their pubertal status, adolescents with ADHD displayed higher positivity for mumps (100% vs. 74.4%, p=0.043). Most of the patients were diagnosed with ADHD-Combined or Hyperactive/Impulsive Subtypes (56.6%) while 43.3% were diagnosed with ADHD-predominantly inattentive type. When patients with subtypes of ADHD were compared in terms of seropositivity, it was found that patients with ADHD-Combined/Hyperactive-Impulsive subtypes had significantly elevated reactions for Rubella (100% vs. 88.5%, p=0.044). Conclusion: Although limited to a single center and may be prone to sampling biases, our results may support the notion that immune reactions may be related with ADHD among children and adolescents. Further, prospective studies from multiple centers are needed to support our findings and establish causality.en_US
dc.identifier.doi10.4314/ahs.v14i2.21
dc.identifier.endpage445en_US
dc.identifier.issn1680-6905
dc.identifier.issn1729-0503
dc.identifier.issue2en_US
dc.identifier.pmid25320595en_US
dc.identifier.scopus2-s2.0-84902357821en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage439en_US
dc.identifier.urihttps://doi.org/10.4314/ahs.v14i2.21
dc.identifier.urihttps://hdl.handle.net/20.500.12491/8033
dc.identifier.volume14en_US
dc.identifier.wosWOS:000344302300022en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorBekdaş, Mervan
dc.institutionauthorTufan, Ali Evren
dc.institutionauthorHakyemez, İsmail Necati
dc.institutionauthorTaş, Tekin
dc.institutionauthorAltunhan, Hüseyin
dc.institutionauthorDemircioğlu, Fatih
dc.institutionauthorKısmet, Erol
dc.language.isoenen_US
dc.publisherMakerere Univ, Fac Meden_US
dc.relation.ispartofAfrican Health Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectADHDen_US
dc.subjectInfectionen_US
dc.subjectImmunologyen_US
dc.subjectMeaslesen_US
dc.subjectRubellaen_US
dc.subjectMumpsen_US
dc.subjectIgGen_US
dc.titleSubclinical immune reactions to viral infections may correlate with child and adolescent diagnosis of attention-deficit/hyperactivity disorder: a preliminary study from Turkeyen_US
dc.typeArticleen_US

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