High-sensitivity C-reactive protein levels in cerebrospinal fluid and serum in severe head injury: relationship to tumor necrosis factor-alpha and interleukin-6

dc.authorid0000-0002-1273-0604en_US
dc.authorid0000-0002-3312-3192en_US
dc.authorid0000-0001-6539-7254en_US
dc.authorid0000-0002-1878-0696
dc.authorid000-0002-8830-9525
dc.authorid0000-0001-5999-0465
dc.contributor.authorİş, Merih
dc.contributor.authorCoşkun, Abdurrahman
dc.contributor.authorSanus, Galip Zihni
dc.contributor.authorTanrıverdi, Taner
dc.contributor.authorKafadar, Ali Metin
dc.contributor.authorHanımoğlu, Hakan
dc.contributor.authorGezen, Ferruh
dc.date.accessioned2021-06-23T19:19:40Z
dc.date.available2021-06-23T19:19:40Z
dc.date.issued2007
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractRecent studies have demonstrated the role of high-sensitivity C-reactive protein (hsCRP) in inflammatory diseases; however, it is unclear whether this molecule has a role after severe head injury (SHI). Our aim was to evaluate the levels of hsCRP in both cerebrospinal fluid (CSF) and serum from patients after SHI. The study focused on 11 patients with SHI and evaluated CSF and serum levels of hsCRP, tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) in a 10-day period following the head trauma. The values were compared with those from nine control patients, who had normal pressure hydrocephalus. In the CSF and serum of the patients after SHI HsCRP was found to be significantly higher, at all times, than in the controls; TNF-alpha and IL-6 levels were also higher in these patients. However, hsCRP levels did not correlate with either TNF-alpha or IL-6. TNF-alpha and IL-6 increased during the period immediately following the SHI and intrathecal levels were always higher than those of the serum. This study demonstrates for the first time that hsCRP reaches high levels in both CSF and serum in patients with SHI, and it may therefore be used as an inflammatory index. This finding suggests a need for further studies in this area, which are larger in scope than the present study.en_US
dc.identifier.doi10.1016/j.jocn.2006.05.020
dc.identifier.endpage1171en_US
dc.identifier.issn0967-5868
dc.identifier.issue12en_US
dc.identifier.pmid17884503en_US
dc.identifier.scopus2-s2.0-36049009328en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1163en_US
dc.identifier.urihttps://doi.org/10.1016/j.jocn.2006.05.020
dc.identifier.urihttps://hdl.handle.net/20.500.12491/5984
dc.identifier.volume14en_US
dc.identifier.wosWOS:000251647300005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorİş, Merih
dc.institutionauthorCoşkun, Abdurrahman
dc.institutionauthorGezen, Ferruh
dc.language.isoenen_US
dc.publisherChurchill Livingstoneen_US
dc.relation.ispartofJournal Of Clinical Neuroscienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjecthsCRPen_US
dc.subjectIL-6en_US
dc.subjectInflammationen_US
dc.subjectSevere Head Injuryen_US
dc.subjectTNF-alphaen_US
dc.titleHigh-sensitivity C-reactive protein levels in cerebrospinal fluid and serum in severe head injury: relationship to tumor necrosis factor-alpha and interleukin-6en_US
dc.typeArticleen_US

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