The effects of Ankaferd Blood Stopper on the recovery process in an experimental oesophageal perforation model

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dc.authorid0000-0002-0921-852X
dc.authorid0000-0002-4600-1290
dc.authorid0000-0003-4096-4261
dc.contributor.authorSarıkaş, Necla Gürbüz
dc.contributor.authorKorkmaz, Tanzer
dc.contributor.authorKahramansoy, Nurettin
dc.contributor.authorKılıçgün, Ali
dc.contributor.authorBoran, Çetin
dc.date.accessioned2021-06-23T19:42:34Z
dc.date.available2021-06-23T19:42:34Z
dc.date.issued2015
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground: Oesophageal perforation is a life-threatening pathology that is generally treated conservatively; however, surgical procedures are frequently performed. A topical haemostatic agent, Ankaferd Blood Stopper (ABS), also has beneficial wound-healing effects. Aims: This study aimed to determine the effects of ABS following experimental oesophageal perforations. Study Design: Animal experiment. Methods: The experimental rats were classified into 6 groups (with 7 rats in each group). Pairs of groups (primary repair alone and primary repair + ABS) were terminated in the 1st, 2nd, and 3rd weeks following injury. The oesophageal perforations, which were 8-10 mm in length, were created using a nasogastric tube. The perforation sites were repaired with a 6-0 polyglactine thread in the primary repair groups. Additionally, ABS was sprayed over the perforation site in the treatment groups. Each oesophagus was evaluated histopathologically. Results: There were fewer microabscesses and areas of necrosis in the ABS groups compared with the primary repair groups. The histopathological evaluation revealed that the ABS groups had less inflammation and more re-epithelisation compared to the primary repair groups (p=0.002 and p=0.003, respectively). Fibrosis in the ABS groups was moderate in the 2nd week and mild in the 3rd week. Comparing the groups with respect to the time intervals, only the 1st week groups showed a significant difference in terms of re-epithelialisation (p=0.044). Conclusion: Topical ABS application on the repaired experimental oesophageal perforation regions led to positive wound-healing effects compared with the rats that were administered the primary repair alone.en_US
dc.identifier.doi10.5152/balkanmedj.2015.15459
dc.identifier.endpage100en_US
dc.identifier.issn2146-3123
dc.identifier.issn2146-3131
dc.identifier.issue1en_US
dc.identifier.pmid25759779en_US
dc.identifier.scopus2-s2.0-84922948610en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage96en_US
dc.identifier.trdizinid168059en_US
dc.identifier.urihttps://doi.org/10.5152/balkanmedj.2015.15459
dc.identifier.urihttps://hdl.handle.net/20.500.12491/8533
dc.identifier.urihttps://app.trdizin.gov.tr/makale/TVRZNE1EVTVPUT09
dc.identifier.volume32en_US
dc.identifier.wosWOS:000351489300015en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKorkmaz, Tanzer
dc.institutionauthorKahramansoy, Nurettin
dc.institutionauthorKılıçgün, Ali
dc.institutionauthorBoran, Çetin
dc.language.isoenen_US
dc.publisherAvesen_US
dc.relation.ispartofBalkan Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAnkaferd Blood Stopperen_US
dc.subjectExperimentalen_US
dc.subjectOesophageal Perforationen_US
dc.titleThe effects of Ankaferd Blood Stopper on the recovery process in an experimental oesophageal perforation modelen_US
dc.typeArticleen_US

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