Eyes are mirror of the brain: Comparison of multiple sclerosis patients and healthy controls using OCT

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dc.authorid0000-0003-4468-3985en_US
dc.authorid0000-0002-8249-2621
dc.authorid0000-0001-8616-832X
dc.authorid0000-0001-5524-5767
dc.contributor.authorDoğan, Ümit
dc.contributor.authorUlaş, Fatih
dc.contributor.authorTürkoğlu, Şule Aydın
dc.contributor.authorÖgün, Muhammed Nur
dc.contributor.authorAğca, Sümeyra
dc.date.accessioned2021-06-23T19:50:53Z
dc.date.available2021-06-23T19:50:53Z
dc.date.issued2019
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractObjective: To evaluate the thickness of choroid and retinal nerve fiber layer (RNFL) in multiple sclerosis (MS) patients with and without optic neuritis using enhanced depth imaging optical coherence tomography (EDI-OCT).Methods: In this cross-sectional study, both eyes of 52MS patients [n=104 eyes; 62 eyes of MS patients without optic neuritis (MS-NON) and 42 eyes of MS patients with optic neuritis (MS-ON)] and only one eye of 36 healthy control subjects (n=36 eyes) were evaluated. Complete ophthalmologic examination and EDI-OCT scanning were completed for all participants. Choroidal thickness measurements were executed at three different points.Results: Choroidal thickness measurements were similar between MS patients and healthy control subjects. However, the mean subfoveal choroidal thickness was increased significantly in MS-ON group (399.1382.91 mu m) compared to MS-NON group (342.71 +/- 82.46 mu m; p=0.004). Mean RNFL thickness was significantly reduced in MS patients (90.42 +/- 13.31 mu m) compared to healthy controls (101.18 +/- 10.75 mu m; p<0.001). Moreover, temporal RNFL thickness was significantly thinner in MS-ON group (54 +/- 14.50 mu m) than MS-NON group (62.15 +/- 15.88 mu m; p=0.01). In MS patients, temporal RNFL thickness was correlated with both Expanded Disability Status Score (r=0.383; p<0.001) and longer disease duration (r=-0.202; p=0.04).Conclusion: The results of the present study suggest that RNFL thickness can be used as an important parameter while following up with MS patients. However, more studies using EDI-OCT are required with larger MS patient groups and automated method.en_US
dc.identifier.doi10.1080/00207454.2019.1576660
dc.identifier.endpage855en_US
dc.identifier.issn0020-7454
dc.identifier.issn1563-5279
dc.identifier.issue9en_US
dc.identifier.pmid30696321en_US
dc.identifier.scopus2-s2.0-85068259070en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage848en_US
dc.identifier.urihttps://doi.org/10.1080/00207454.2019.1576660
dc.identifier.urihttps://hdl.handle.net/20.500.12491/9880
dc.identifier.volume129en_US
dc.identifier.wosWOS:000474711400003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorDoğan, Ümit
dc.institutionauthorUlaş, Fatih
dc.institutionauthorTürkoğlu, Şule Aydın
dc.institutionauthorÖgün, Muhammed Nur
dc.institutionauthorAğca, Sümeyra
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofInternational Journal Of Neuroscienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChoroiden_US
dc.subjectExpanded Disability Status Scaleen_US
dc.subjectMultiple Sclerosisen_US
dc.subjectOptical Coherence Tomographyen_US
dc.subjectRetinal Nerve Fiber Layeren_US
dc.titleEyes are mirror of the brain: Comparison of multiple sclerosis patients and healthy controls using OCTen_US
dc.typeArticleen_US

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