Effects of lycopene in intestinal ischemia reperfusion injury via intestinal immunoglobulin A

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dc.authorid0000-0002-1426-0247en_US
dc.authorid0000-0002-2860-1794en_US
dc.authorid0000-0002-8317-7092en_US
dc.contributor.authorİkiz, Özgür
dc.contributor.authorKahramansoy, Nurettin
dc.contributor.authorErkol, Hayri
dc.contributor.authorKoçoğlu, Esra
dc.contributor.authorFırat, Tülin
dc.date.accessioned2023-07-10T11:37:38Z
dc.date.available2023-07-10T11:37:38Z
dc.date.issued2021en_US
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground: Intestinal ischemia causes an inflammatory response that may become intense by reperfusion and result in bacterial translocation. Intestinal immunoglobulin A is known to be a barrier against bacterial translocation. Lycopene is a compound with antioxidant and anti-inflammatory properties. We hypothesized that lycopene has positive effects in ischemia-reperfusion of the intestine through the intestinal IgA. Material and methods: Twenty-eight Wistar albino rats were separated into four groups: sham, control, lycopene-administered-before-ischemia (L-pre), and lycopene-administered-after-reperfusion groups. Histopathologic changes, intestinal immunoglobulin A levels, and bacterial translocation were evaluated after the ischemia-reperfusion period of 0.5-12 h. Results: Histopathologic changes, intestinal immunoglobulin A, and bacterial translocation levels in the L-pre group were similar to those in the sham group. Administration of the lycopene after reperfusion showed just a slight protective effect. However, the L-pre group had significantly fewer histopathologic changes when compared with changes in the control (P = 0.011). Intestinal immunoglobulin A level in the L-pre group was found to be higher than that in the control group (P = 0.014). Bacterial translocation levels in the blood and mesenteric lymph nodes, in the L-pre group, were lower than those in the control group (P = 0.0027 and P = 0.0097, respectively). Conclusions: Lycopene limited intestinal damage, reduced loss of intestinal immunoglobulin A and decreased bacterial translocation when administered before the ischemia-reperfusion injury.en_US
dc.identifier.citationİkiz, Ö., Kahramansoy, N., Erkol, H., Koçoğlu, E., & Fırat, T. (2021). Effects of lycopene in intestinal ischemia reperfusion injury via intestinal immunoglobulin A. Journal of Surgical Research, 267, 63-70.en_US
dc.identifier.doi10.1016/j.jss.2021.04.039
dc.identifier.endpage70en_US
dc.identifier.issn0022-4804
dc.identifier.issn1095-8673
dc.identifier.pmid34130240en_US
dc.identifier.scopus2-s2.0-85107801085en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage63en_US
dc.identifier.urihttp://dx.doi.org/10.1016/j.jss.2021.04.039
dc.identifier.urihttps://hdl.handle.net/20.500.12491/11262
dc.identifier.volume267en_US
dc.identifier.wosWOS:000702685500009en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorİkiz, Özgür
dc.institutionauthorKahramansoy, Nurettin
dc.institutionauthorErkol, Hayri
dc.institutionauthorKoçoğlu, Esra
dc.institutionauthorFırat, Tülin
dc.language.isoenen_US
dc.publisherACADEMIC PRESS INC ELSEVIER SCIENCEen_US
dc.relation.ispartofJournal of Surgical Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLycopeneen_US
dc.subjectMesenteric Ischemiaen_US
dc.subjectIntestinal Ischemia Reperfusionen_US
dc.subjectImmunoglobulin Aen_US
dc.subjectBacterial Translocationen_US
dc.subjectIntestinal Barrieren_US
dc.titleEffects of lycopene in intestinal ischemia reperfusion injury via intestinal immunoglobulin Aen_US
dc.typeArticleen_US

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