Locomotor differences in Mongolian gerbils with the effects of midazolam administration in the form of eye drops

Basit Öğe Kaydı
dc.authorid0000-0002-1630-2033en_US
dc.authorid0000-0003-4139-5080
dc.authorid0000-0001-8707-4034
dc.authorid0000-0002-4229-6589
dc.authorid0000-0001-8741-5548
dc.contributor.authorAkkaya, Akcan
dc.contributor.authorTekelioğlu, Ümit Yaşar
dc.contributor.authorDemirhan, Abdullah
dc.contributor.authorErdurmuş, Mesut
dc.contributor.authorApuhan, Tayfun
dc.contributor.authorBayır, Hakan
dc.contributor.authorAyaz, Erol
dc.date.accessioned2021-06-23T19:36:50Z
dc.date.available2021-06-23T19:36:50Z
dc.date.issued2014
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground: Midazolam is a sedative-hypnotic agent with amnestic and anticonvulsant properties that can be administrated to mammals through various routes, such as intravenous, intramuscular, oral, intrathecal, rectal, and buccal. Midazolam administration in the form of eye drops through the conjunctiva is not reported in the literature. Aim: This study aims to demonstrate the possible central nervous system effects of midazolam administration as eyes drops in Mongolian gerbils. Materials and Methods: Fourteen gerbils were randomly assigned to one of two equal sized groups. The active arm received 2 ml of 10 mg midazolam as eye drops in both eyes. Control group received a total of 2 ml of physiological saline(0.9% NaCl). We subjected the gerbils to an adapted "Open Field" to determine the possible effects on central nervous system of midazolam. Gerbils were allowed to move freely in the open field. Before and after the drug administration, locomotor activities of each gerbil have been recorded. Frequency of loss of righting reflex was quantified. Results: Conjunctival midazolam administration resulted with the transient loss of righting reflex (p=0.017) and suppressed exploration motion (p=0.018) in the open field test compared to control subjects. Conclusions: In the present study, administration of conjunctival midazolam as an eye drop may affect gerbil's locomotor activities and open field behaviors. We argue that, using a sedative and anticonvulsive drug such as midazolam via conjunctival route may be useful in some clinical situations. Therefore, it could be beneficial to develop a new conjunctival formulation of midazolam. Also, there is a need for trials in humans with pharmacokinetic studies.en_US
dc.identifier.doi10.4314/ahs.v14i1.30
dc.identifier.endpage200en_US
dc.identifier.issn1680-6905
dc.identifier.issn1729-0503
dc.identifier.issue1en_US
dc.identifier.pmid26060479en_US
dc.identifier.scopus2-s2.0-84896101134en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage195en_US
dc.identifier.urihttps://doi.org/10.4314/ahs.v14i1.30
dc.identifier.urihttps://hdl.handle.net/20.500.12491/8063
dc.identifier.volume14en_US
dc.identifier.wosWOS:000335444500030en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorAkkaya, Akcan
dc.institutionauthorTekelioğlu, Ümit Yaşar
dc.institutionauthorDemirhan, Abdullah
dc.institutionauthorErdurmuş, Mesut
dc.institutionauthorApuhan, Tayfun
dc.institutionauthorBayır, Hakan
dc.institutionauthorAyaz, Erol
dc.language.isoenen_US
dc.publisherMakerere Univ, Fac Meden_US
dc.relation.ispartofAfrican Health Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectRighting Reflexen_US
dc.subjectConjunctival Midazolamen_US
dc.subjectEye Dropen_US
dc.subjectNew Administration Routeen_US
dc.titleLocomotor differences in Mongolian gerbils with the effects of midazolam administration in the form of eye dropsen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
akcan-akkaya- 8063.pdf
Boyut:
316.56 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam metin/Full text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Cerrahi Tıp Bilimleri Bölümü Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
Temel Tıp Bilimleri Bölümü Koleksiyonu