The efficacy of cystatin c assay in the prediction of glomerular filtration rate. Is it a more reliable marker for renal failure?

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dc.authorid0000-0003-4740-2333
dc.authorid0000-0002-7613-2240
dc.authorid0000-0003-1937-9244
dc.contributor.authorBicik, Zerrin
dc.contributor.authorBahçebaşı, Talat
dc.contributor.authorKulaksızoğlu, Sevsen
dc.contributor.authorYavuz, Özlem
dc.date.accessioned2021-06-23T19:18:38Z
dc.date.available2021-06-23T19:18:38Z
dc.date.issued2005
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractWe determined the sensitivity, specificity, receiver operating characteristics and correlation between. cystatin C (cysC) and two widely used markers of renal function, creatinine clearance and serum creatinine, in 244 patients (84 diabetics, 84 hypertensive an 76 healthy subjects). Renal failure was defined as creatinine clearance of less than either 80 or 60 mL/min. Variables were evaluated for two definitions of renal failure and compared between patient groups. Correlation coefficients with cysC were -0.87 for creatinine clearance and 0.92 for creatinine in patients with hypertension; - 0.90 for creatinine clearance and 0.97 for creatinine in diabetics; and -0.61 for creatinine clearance and 0.94 for creatinine in the control group. The receiver operating characteristic curves with a cut-off value of 60 mL/min were similar for creatinine and cysC, while at 80 mL/min they were 0.626 for creatinine and 0.813 for cysC levels. We classified the patients into three groups with respect to creatinine clearance (1, > 80 mL/min; 2, 60-80 mL/min; 3, < 60 mL/min). Mean creatinine (p < 0.0001) and cysC (p < 0.0001) levels were significantly different between all the groups. Sensitivity, specificity and predictive values were higher for cysC levels, particularly in diabetics and hypertensive patients. The current study suggests that cysC is preferable for detecting temporal changes in renal function in the early stages of renal insufficiency.en_US
dc.identifier.doi10.1515/CCLM.2005.144
dc.identifier.endpage861en_US
dc.identifier.issn1434-6621
dc.identifier.issn1437-4331
dc.identifier.issue8en_US
dc.identifier.pmid16201897en_US
dc.identifier.scopus2-s2.0-26844462213en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage855en_US
dc.identifier.urihttps://doi.org/10.1515/CCLM.2005.144
dc.identifier.urihttps://hdl.handle.net/20.500.12491/5774
dc.identifier.volume43en_US
dc.identifier.wosWOS:000231658400011en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorBicik, Zerrin
dc.institutionauthorBahçebaşı, Talat
dc.institutionauthorYavuz, Özlem
dc.language.isoenen_US
dc.publisherWalter De Gruyter Gmbhen_US
dc.relation.ispartofClinical Chemistry And Laboratory Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCreatinineen_US
dc.subjectCystatin Cen_US
dc.subjectDiabetesen_US
dc.subjectGlomerular Filtration Rate (GFR)en_US
dc.subjectHypertensionen_US
dc.titleThe efficacy of cystatin c assay in the prediction of glomerular filtration rate. Is it a more reliable marker for renal failure?en_US
dc.typeArticleen_US

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