Transcription of the HXT4 gene is regulated by Gcr1p and Gcr2p in the yeast S-cerevisiae

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dc.authorid0000-0001-7128-6948
dc.authorid0000-0002-9221-6356
dc.contributor.authorTürkel, Sezai
dc.contributor.authorBisson, Linda F.
dc.date.accessioned2021-06-23T19:17:16Z
dc.date.available2021-06-23T19:17:16Z
dc.date.issued1999
dc.departmentBAİBÜ, Fen Edebiyat Fakültesi, Biyoloji Bölümüen_US
dc.description.abstractGlucose transport and glycolysis are two sequential events which are regulated by both physiological and environmental signals in the yeast Saccharomyces cerevisiae. Transcription of the HXT4 gene was found to be regulated by Gcr1p and Gcr2p, transcription factors that are required for the regulated high level transcriptions of glycolytic genes. Transcription of HXT4 decreased about 35-fold in gcr1 mutant and two-fold in gcr2 mutant yeast cells. However, transcription of other HXT genes was not affected at a significant level by gcr1 or gcr2 mutations. Overproduction of Gcr1p from an inducible promoter resulted in a 15-64% increase in transcription of HXT4, depending on the growth conditions. Gel mobility shift assays performed with the purified DNA binding domain of Gcr1p and the UAS region of the HXT4 gene showed that Gcr1p interacts directly with multiple sites on the HXT4 UAS region. These results indicate that Gcr1p and Gcr2p coordinate the transcription of HXT4 and glycolytic genes.en_US
dc.identifier.doi10.1002/(SICI)1097-0061(199908)15:11<1045
dc.identifier.endpage1057en_US
dc.identifier.issn0749-503X
dc.identifier.issue11en_US
dc.identifier.pmid10455229en_US
dc.identifier.scopus2-s2.0-18844479099en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1045en_US
dc.identifier.urihttps://doi.org/10.1002/(SICI)1097-0061(199908)15:11<1045
dc.identifier.urihttps://hdl.handle.net/20.500.12491/5327
dc.identifier.volume15en_US
dc.identifier.wosWOS:000082028500004en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorTürkel, Sezai
dc.language.isoenen_US
dc.publisherJohn Wiley & Sons Ltden_US
dc.relation.ispartofYeasten_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectYeasten_US
dc.subjectHexose Transportersen_US
dc.subjectGcr1pen_US
dc.subjectTranscriptional Regulationen_US
dc.titleTranscription of the HXT4 gene is regulated by Gcr1p and Gcr2p in the yeast S-cerevisiaeen_US
dc.typeArticleen_US

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