Quercetin- and caffeic acid-functionalized chitosan-capped colloidal silver nanoparticles: One-pot synthesis, characterization, and anticancer and antibacterial activities

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dc.authorid0000-0003-2940-3172en_US
dc.authorid0000-0002-0386-589Xen_US
dc.authorid0000000260117775en_US
dc.authorid0000-0003-2739-7725en_US
dc.authorid0000-0001-5380-0819en_US
dc.authorid0000-0003-2933-5296en_US
dc.contributor.authorKurt, Akif Hakan
dc.contributor.authorOlutaş, Elif Berna
dc.contributor.authorAvcıoğlu, Fatma
dc.contributor.authorKarakuş, Hamza
dc.contributor.authorSungur, Mehmet Ali
dc.contributor.authorÖztabağ, Cansu Kara
dc.contributor.authorYıldırım, Muhammet
dc.date.accessioned2024-02-05T13:19:38Z
dc.date.available2024-02-05T13:19:38Z
dc.date.issued2023en_US
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionThis study was funded by Bolu Abant Izzet Baysal University, Scientific Research Projects Division (BAP grant no. 2020.08.36.1449) .en_US
dc.description.abstractThe presented study comprises the one-pot synthesis and the characterization of quercetin-and caffeic acid-functionalized chitosan-capped colloidal silver nanoparticles (Ch/Q-and Ch/CA-Ag NPs), and their antibacterial and anticancer activities. The formation of Ch/Q-and Ch/CA-Ag NPs has been confirmed by ultraviolet-visible (UV-vis) spectroscopy, Fourier-transform infrared (FTIR) spectroscopy, and transmission electron microscopy (TEM). The characteristic surface plasmon resonance (SPR) absorption band has been found at 417 and 424 nm for Ch/Q-and Ch/CA-Ag NPs, respectively. The formation of a chitosan shell comprising quercetin and caffeic acid, which surround the colloidal core Ag NPs, was confirmed by UV-vis, and FTIR analyses, and moni-tored by TEM microscopy. The size of nanoparticles has been determined as 11.2 and 10.3 nm for Ch/Q-and Ch/CA-Ag, respec-tively. The anticancer activity of Ch/Q-and Ch/CA-Ag NPs has been evaluated against U-118 MG (human glioblastoma) and ARPE-19 (human retinal pigment epithelium) cells. Both NPs showed anticancer activity, but Ch/Q-Ag NPs seemed to be more effective on cancer cell lines (U-118 MG) in comparison to healthy ones (ARPE-19). Furthermore, the antibacterial activity of Ch/Q-and Ch/CA-Ag NPs against Gram-negative (P. aeruginosa and E. coli) and Gram-positive (S. aureus and S. epidermidis) bacteria was determined, and dose-dependent antibacterial effects were found.en_US
dc.description.sponsorshipBolu Abant Izzet Baysal University, Scientific Research Projects Division (BAP) [2020.08.36.1449]en_US
dc.identifier.citationKurt, A. H., Olutas, E. B., Avcioglu, F., Karakuş, H., Sungur, M. A., Oztabag, C. K., & Yıldırım, M. (2023). Quercetin-and caffeic acid-functionalized chitosan-capped colloidal silver nanoparticles: one-pot synthesis, characterization, and anticancer and antibacterial activities. Beilstein Journal of Nanotechnology, 14(1), 362-376.en_US
dc.identifier.doi10.3762/bjnano.14.31
dc.identifier.endpage376en_US
dc.identifier.issn2190-4286
dc.identifier.pmid36998241en_US
dc.identifier.scopus2-s2.0-85153768953en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage362en_US
dc.identifier.urihttp://dx.doi.org/10.3762/bjnano.14.31
dc.identifier.urihttps://hdl.handle.net/20.500.12491/11978
dc.identifier.volume14en_US
dc.identifier.wosWOS:000956622700001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKurt, Akif Hakan
dc.institutionauthorOlutaş, Elif Berna
dc.institutionauthorAvcıoğlu, Fatma
dc.institutionauthorKarakuş, Hamza
dc.institutionauthorÖztabağ, Cansu Kara
dc.institutionauthorYıldırım, Muhammet
dc.language.isoenen_US
dc.publisherBeilstein-Instituten_US
dc.relation.ispartofBeilstein Journal of Nanotechnologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAg NPsen_US
dc.subjectAnticancer and Antibacterial Effectsen_US
dc.subjectCaffeic Aciden_US
dc.subjectChitosanen_US
dc.subjectOne-Pot Synthesisen_US
dc.subjectQuercetinen_US
dc.subjectU-118 MG and ARPE-19 Cellsen_US
dc.titleQuercetin- and caffeic acid-functionalized chitosan-capped colloidal silver nanoparticles: One-pot synthesis, characterization, and anticancer and antibacterial activitiesen_US
dc.typeArticleen_US

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