A combination of plasma DAO and citrulline levels as a potential marker for acute mesenteric ischemia

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dc.authorid0000-0002-4060-3354en_US
dc.authorid0000-0003-4096-4261
dc.authorid0000-0002-1426-0247
dc.contributor.authorÇakmaz, Rıdvan
dc.contributor.authorBüyükaşık, Oktay
dc.contributor.authorKahramansoy, Nurettin
dc.contributor.authorErkol, Mehmet Hayri
dc.contributor.authorÇöl, Cavit
dc.contributor.authorBoran, Çetin
dc.contributor.authorBuğdaycı, Güler
dc.date.accessioned2021-06-23T19:35:08Z
dc.date.available2021-06-23T19:35:08Z
dc.date.issued2013
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractIntroduction: There is no valid and reliable diagnostic test for early diagnosis of acute mesenteric ischemia (AMI). The aim of this study was to measure the plasma levels of diamine oxidase (DAO) and citrulline in AMI to gain insight into its early diagnosis. Material and methods: A total of 21 Wistar albino rats were divided into three groups, that is, control group, short-term ischemia group, and prolonged ischemia group. The superior mesenteric artery was occluded for 15 min in the short-term ischemia group and for 12 h in the prolonged ischemia group. Twelve hours later, the experiment was terminated and plasma DAO and citrulline levels were measured. Intestinal tissue was evaluated for the histopathological changes. Results: Compared to the control group, the short-term and prolonged ischemia groups showed significant increases in the plasma levels of DAO, whereas the plasma citrulline levels decreased significantly. Prolonged ischemia caused a larger increase in the plasma DAO levels and a larger decrease in the plasma citrulline levels compared to the short-term ischemia (p =0.011 and p =0.021, respectively). Intestinal damage was shown to develop more in the prolonged ischemia group (p =0.001). Conclusion: In the early period of AMI, the plasma DAO levels increase while citrulline levels decrease, and the extent of these changes depends on the duration of ischemia.en_US
dc.identifier.doi10.3402/ljm.v8i0.20596
dc.identifier.issn1993-2820
dc.identifier.issn1819-6357
dc.identifier.pmid28156218en_US
dc.identifier.scopus2-s2.0-84875682499en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.3402/ljm.v8i0.20596
dc.identifier.urihttps://hdl.handle.net/20.500.12491/7718
dc.identifier.volume8en_US
dc.identifier.wosWOS:000317349000001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKahramansoy, Nurettin
dc.institutionauthorErkol, Mehmet Hayri
dc.institutionauthorÇöl, Cavit
dc.institutionauthorBoran, Çetin
dc.institutionauthorBuğdaycı, Güler
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofLibyan Journal Of Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAnimal Modelen_US
dc.subjectExperimentalen_US
dc.subjectIntestinesen_US
dc.subjectDiamine Oxidaseen_US
dc.subjectCitrullineen_US
dc.titleA combination of plasma DAO and citrulline levels as a potential marker for acute mesenteric ischemiaen_US
dc.typeArticleen_US

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