Association between vitamin D levels and lower-extremity deep vein thrombosis: A case-control study

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dc.authorid0000-0002-6107-2943en_US
dc.authorid0000-0003-0001-9329en_US
dc.authorid0000-0003-0021-6509en_US
dc.authorid0000-0002-3394-2438en_US
dc.authorid0000-0003-3655-1595en_US
dc.contributor.authorKorkmaz, Ufuk Turan Kürşat
dc.contributor.authorErsoy, Süleyman
dc.contributor.authorYüksel, Ahmet
dc.contributor.authorÇelik, Hümeyra
dc.contributor.authorUçaroğlu, Erhan Renan
dc.date.accessioned2023-07-12T08:26:55Z
dc.date.available2023-07-12T08:26:55Z
dc.date.issued2021en_US
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractBACKGROUND: Vitamin D has relationships with pathogenesis and inflammation pathways in many diseases. Its deficiency may make clinicians think not only of supplementation but also of presence of other diseases. OBJECTIVE: To investigate the relationship between vitamin D levels and deep vein thrombosis (DVT), given that reduced levels are related to increased risk of cardiovascular diseases. DESIGN AND SETTING: Case-control study conducted in the cardiovascular surgery and family medicine departments of a hospital in Turkey. METHODS: A total of 280 participants were included: 140 each in the DVT and control groups. Basic clinical characteristics, comorbidities and serum 25-hydroxyvitamin D (25(OH)D) levels were recorded and then compared between the groups. Serum 25(OH)D levels were also evaluated separately in three subgroups (sufficient, insufficient and deficient). RESULTS: Serum 25(OH)D levels were significantly lower in the DVT group than in the controls (P < 0.001). Females in the DVT group had lower 25(OH)D levels than those in the control group (P = 0.002). Nonetheless, the median 25(OH)D level (16.41 ng/ml) of the control group was still below the reference value. Logistic regression analysis showed that 25(OH)D was a significant predictor of DVT. Weight, height and body mass index, which all presented interaction, were significant in the logistic regression analysis but not in individual analyses. CONCLUSION: The serum vitamin D levels of DVT patients were lower than those of controls. If the results obtained from our study are supported by further large-scale randomized controlled trials, vitamin D replacement may be brought into the agenda for protection against DVT.en_US
dc.identifier.citationKorkmaz, U. T. K., Ersoy, S., Yuksel, A., Celik, H., Ucaroglu, E. R., Velioglu, Y., ... & Erdem, K. (2021). Association between vitamin D levels and lower-extremity deep vein thrombosis: a case-control study. Sao Paulo Medical Journal, 139, 279-284.en_US
dc.identifier.doi10.1590/1516-3180.2020.0457.R1.04022021
dc.identifier.endpage284en_US
dc.identifier.issn1516-3180
dc.identifier.issue3en_US
dc.identifier.pmid34076230en_US
dc.identifier.scopus2-s2.0-85107433449en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage279en_US
dc.identifier.urihttp://dx.doi.org/10.1590/1516-3180.2020.0457.R1.04022021
dc.identifier.urihttps://hdl.handle.net/20.500.12491/11276
dc.identifier.volume139en_US
dc.identifier.wosWOS:000659295300011en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKorkmaz, Ufuk Turan Kürşat
dc.institutionauthorYüksel, Ahmet
dc.institutionauthorÇelik, Hümeyra
dc.institutionauthorUçaroğlu, Erhan Renan
dc.language.isoenen_US
dc.publisherASSOCIACAO PAULISTA MEDICINAen_US
dc.relation.ispartofSao Paulo Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectVitamin Den_US
dc.subjectVenous Thrombosisen_US
dc.subject25-Hydroxyvitamin D3 1-Alpha-Hydroxylaseen_US
dc.subjectVenous Thromboembolismen_US
dc.subjectD Deficiencyen_US
dc.subjectRisken_US
dc.titleAssociation between vitamin D levels and lower-extremity deep vein thrombosis: A case-control studyen_US
dc.typeArticleen_US

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