Inhibitory effects of topical cyclosporine A 0.05 % on immune-mediated corneal neovascularization in rabbits

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dc.authorid0000-0002-4552-0048
dc.contributor.authorBucak, Yasin Yücel
dc.contributor.authorErdurmuş, Mesut
dc.contributor.authorTerzi, Elçin Hakan
dc.contributor.authorKükner, Aysel
dc.contributor.authorÇelebi, Serdal
dc.date.accessioned2021-06-23T19:34:10Z
dc.date.available2021-06-23T19:34:10Z
dc.date.issued2013
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description30th Congress of the European-Society-of-Cataract-and-Refractive-Surgeons (ESCRS) -- SEP 08-12, 2012 -- Milan, ITALYen_US
dc.description.abstractWe aimed to study the inhibitory effects of topical cyclosporine A (CsA) 0.05 % on immune-mediated corneal neovascularization, and to compare its efficacy with those of dexamethasone 0.1 % and bevacizumab 0.5 %. Immune-mediated corneal neovascularization was created in 36 right eyes of 36 rabbits. The rabbits were then randomized into four groups. Group I received CsA 0.05 %, Group II received dexamethasone 0.1 %, Group III received bevacizumab 0.5 %, and Group IV received isotonic saline twice a day for 14 days. The corneal surface covered with neovascular vessels was measured on the photographs. The rabbits were then sacrificed and the corneas excised. Paraffin-embedded sections were stained with hematoxylin-eosin and terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling assay. The means of percent area of corneal neovascularization in Group I, II, III, and IV were 24.4 %, 5.9 %, 37.1 %, and 44.1 %, respectively. The inhibitory effect of CsA 0.05 % was found to be better than the effect found in the bevacizumab 0.5 % and control groups (p = 0.03 and p = 0.02, respectively). CsA 0.05 % was found to have significantly lesser inhibitory effects on corneal neovascularization than dexamethasone 0.1 % (p < 0.001). Apoptotic cell density was higher in Group III and Group IV than in Group I and Group II. There was no difference between Group I and Group II in terms of apoptotic cell density (p = 0.7). Topical CsA 0.05 % was shown to have an inhibitory effect on immune-mediated corneal neovascularization in rabbits.en_US
dc.description.sponsorshipEuropean Soc Cataract & Refract Surgen_US
dc.identifier.doi10.1007/s00417-013-2467-4
dc.identifier.endpage2561en_US
dc.identifier.issn0721-832X
dc.identifier.issn1435-702X
dc.identifier.issue11en_US
dc.identifier.pmid24048578en_US
dc.identifier.scopus2-s2.0-84887150062en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage2555en_US
dc.identifier.urihttps://doi.org/10.1007/s00417-013-2467-4
dc.identifier.urihttps://hdl.handle.net/20.500.12491/7410
dc.identifier.volume251en_US
dc.identifier.wosWOS:000326052700008en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorErdurmuş, Mesut
dc.institutionauthorÇelebi, Serdal
dc.institutionauthorTerzi, Elçin Hakan
dc.institutionauthorKükner, Aysel
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofGraefes Archive For Clinical And Experimental Ophthalmologyen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectArthus Reactionen_US
dc.subjectCyclosporine Aen_US
dc.subjectDexamethasoneen_US
dc.subjectBevacizumaben_US
dc.subjectCorneal Neovascularizationen_US
dc.titleInhibitory effects of topical cyclosporine A 0.05 % on immune-mediated corneal neovascularization in rabbitsen_US
dc.typeConference Objecten_US

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