Active shrinkage protects neurons following axonal transection

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dc.authorid0000-0002-6393-1465en_US
dc.authorid0000-0001-9037-5217en_US
dc.authorid0000-0001-9403-2844en_US
dc.authorid0000-0003-0196-2693en_US
dc.authorid0000-0003-3279-1524en_US
dc.contributor.authorAydın, Mehmet Şerif
dc.contributor.authorBay, Sadık
dc.contributor.authorYiğit, Esra Nur
dc.contributor.authorÖzgül, Cemil
dc.contributor.authorOğuz, Elif Kaval
dc.contributor.authorHim, Aydın
dc.date.accessioned2024-05-24T08:08:32Z
dc.date.available2024-05-24T08:08:32Z
dc.date.issued2023en_US
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.descriptionThis research was funded by Yuzuncu Yil University Directorate of Scientific Research Projects, grant TF073 (G.O.) and the Scientific and Technological Research Council of Turkey (TUBITAK) , grant 107S358 (G.O.) .en_US
dc.description.abstractTrauma, vascular events, or neurodegenerative processes can lead to axonal injury and eventual transec(axotomy). Neurons can survive axotomy, yet the underlying mechanisms are not fully understood. Excessive water entry into injured neurons poses a particular risk due to swelling and subsequent death. Using in vitro and in vivo neurotrauma model systems based on laser transection and surgical nerve cut, demonstrated that axotomy triggers actomyosin contraction coupled with calpain activity. As a consequence, neurons shrink acutely to force water out through aquaporin channels preventing swelling and bursting. Inhibiting shrinkage increased the probability of neuronal cell death by about 3-fold. These studies reveal a previously unrecognized cytoprotective response mechanism to neurotrauma and offer fresh perspective on pathophysiological processes in the nervous system.en_US
dc.description.sponsorshipYuzuncu Yil University Directorate of Scientific Research Projects [TF073]; Scientific and Technological Research Council of Turkey (TUBITAK) [107S358]en_US
dc.identifier.citationAydın, M. Ş., Bay, S., Yiğit, E. N., Özgül, C., Oğuz, E. K., Konuk, E. Y., ... & Öztürk, G. (2023). Active shrinkage protects neurons following axonal transection. Iscience, 26(10).en_US
dc.identifier.doi10.1016/j.isci.2023.107715
dc.identifier.endpage16en_US
dc.identifier.issn2589-0042
dc.identifier.issue10en_US
dc.identifier.pmid37701578en_US
dc.identifier.scopus2-s2.0-85170241467en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1en_US
dc.identifier.urihttp://dx.doi.org/10.1016/j.isci.2023.107715
dc.identifier.urihttps://hdl.handle.net/20.500.12491/12155
dc.identifier.volume26en_US
dc.identifier.wosWOS:001073070600001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorHim, Aydın
dc.language.isoenen_US
dc.publisherCell Pressen_US
dc.relation.ispartofIscienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.relation.tubitakScientific and Technological Research Council of Turkey (TUBITAK) [107S358]
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSensory Neuronsen_US
dc.subjectTransgenic Miceen_US
dc.subjectNerve Growthen_US
dc.subjectMyosin-Iien_US
dc.subjectCalciumen_US
dc.subjectAxotomyen_US
dc.titleActive shrinkage protects neurons following axonal transectionen_US
dc.typeArticleen_US

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