Active shrinkage protects neurons following axonal transection
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Dosyalar
Tarih
2023
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Cell Press
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Trauma, vascular events, or neurodegenerative processes can lead to axonal injury and eventual transec(axotomy). Neurons can survive axotomy, yet the underlying mechanisms are not fully understood. Excessive water entry into injured neurons poses a particular risk due to swelling and subsequent death. Using in vitro and in vivo neurotrauma model systems based on laser transection and surgical nerve cut, demonstrated that axotomy triggers actomyosin contraction coupled with calpain activity. As a consequence, neurons shrink acutely to force water out through aquaporin channels preventing swelling and bursting. Inhibiting shrinkage increased the probability of neuronal cell death by about 3-fold. These studies reveal a previously unrecognized cytoprotective response mechanism to neurotrauma and offer fresh perspective on pathophysiological processes in the nervous system.
Açıklama
This research was funded by Yuzuncu Yil University Directorate of Scientific Research Projects, grant TF073 (G.O.) and the Scientific and Technological Research Council of Turkey (TUBITAK) , grant 107S358 (G.O.) .
Anahtar Kelimeler
Sensory Neurons, Transgenic Mice, Nerve Growth, Myosin-Ii, Calcium, Axotomy
Kaynak
Iscience
WoS Q Değeri
Q1
Scopus Q Değeri
Q1
Cilt
26
Sayı
10
Künye
Aydın, M. Ş., Bay, S., Yiğit, E. N., Özgül, C., Oğuz, E. K., Konuk, E. Y., ... & Öztürk, G. (2023). Active shrinkage protects neurons following axonal transection. Iscience, 26(10).
