Two successive pregnancies after ursodeoxycholic acid therapy in a previously infertile woman with antimitochondrial antibody-negative primary biliary cirrhosis

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dc.authorid0000-0002-3073-9098
dc.authorid0000-0003-4740-2333
dc.contributor.authorKorkut, Esin
dc.contributor.authorKısacık, Bünyamin
dc.contributor.authorAkcan, Yusuf
dc.contributor.authorBelenli, Olcay
dc.contributor.authorBicik, Zerrin
dc.contributor.authorYücel, Oǧuz
dc.date.accessioned2021-06-23T18:54:30Z
dc.date.available2021-06-23T18:54:30Z
dc.date.issued2005
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractObjective: To describe the benefit of ursodeoxycholic acid (UDCA) for the initiation and completion of a successful pregnancy in a previously infertile woman with primary biliary cirrhosis. Design: Case report. Setting: A university hospital with relevant departments. Patient(s): A 29-year-old woman with primary biliary cirrhosis and failure to conceive for 6 years. Intervention(s): Establishment of diagnosis with a liver biopsy, pretreatment of patient with UDCA before conception, and continuation of UDCA after first trimester until term. UDCA was used in the second pregnancy again after the first trimester. Main Outcome Measure(s): Achievement of a safe conception and full-term pregnancy. Result(s): Two consecutive successful pregnancies, a healthy 3,250-g male infant and a healthy 3,000-g female infant. The second conception occurred in a period without the use of UDCA, implicating a latent beneficial effect of either UDCA orthe previous pregnancy via some possible immune mechanism. Conclusion(s): Ursodeoxycholic acid could help achieve conception in infertile women with primary biliary cirrhosis. The use of UDCA after the first trimester is shown to be safe in two consecutive pregnancies. Although it cannot be conclusive, the unintentional use of UDCA in the first 20 days after conception did not result in any teratogenicity in the first child. © 2005 by American Society for Reproductive Medicine.en_US
dc.identifier.doi10.1016/j.fertnstert.2004.11.010
dc.identifier.endpage763en_US
dc.identifier.issn0015-0282
dc.identifier.issue3en_US
dc.identifier.pmid15749512en_US
dc.identifier.scopus2-s2.0-14844328691en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage761en_US
dc.identifier.urihttps://doi.org/10.1016/j.fertnstert.2004.11.010
dc.identifier.urihttps://hdl.handle.net/20.500.12491/4463
dc.identifier.volume83en_US
dc.identifier.wosWOS:000227637600039en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKorkut, Esin
dc.institutionauthorAkcan, Yusuf
dc.institutionauthorBelenli, Olcay
dc.institutionauthorBicik, Zerrin
dc.institutionauthorYücel, Oǧuz
dc.language.isoenen_US
dc.publisherElsevier Inc.en_US
dc.relation.ispartofFertility and Sterilityen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectInfertilityen_US
dc.subjectPrimary biliary cirrhosisen_US
dc.subjectUrsodeoxycholic aciden_US
dc.titleTwo successive pregnancies after ursodeoxycholic acid therapy in a previously infertile woman with antimitochondrial antibody-negative primary biliary cirrhosisen_US
dc.typeArticleen_US

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