Effect of sirolimus on renal injury induced by bile duct ligation in rats

Basit Öğe Kaydı
dc.authorid0000-0001-5608-5742
dc.contributor.authorÖztürk, Hülya
dc.contributor.authorTerzi, Akan
dc.contributor.authorÖztürk, Hayrettin
dc.contributor.authorKükner, Aysel
dc.date.accessioned2021-06-23T19:26:46Z
dc.date.available2021-06-23T19:26:46Z
dc.date.issued2010
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractPurpose: To evaluate the effects of sirolimus (SRL) on renal injury in rats with bile duct ligation. Methods: A total of 21 male Sprague-Dawley rats weighing 220-260g were used. Group 1 (Sham-control, n=7) rats were undergone laparotomy alone and bile duct was just dissected from the surrounding tissue. Group 2 rats (BDL/Untreated, n=7) were subjected to bile duct ligation and no drug was applied. Group 3 rats (BDL/SRL, n=7) received a daily dose of sirolimus (0.5 mg.day(-1)xkg(-1) dissolved 1 ml in saline) by orogastric tube for 14 days after BDL. At the end of the two-week period, biochemical and histological evaluation were processed. Results: AST, ALT, AP and TB levels values were decreased in group 3 when compared to group 2. There was no significant difference in serum levels of BUN and creatinine among all the experimental groups. Histological evaluation of the liver of BDL/Untreated group rats demonstrated marked portal fibrosis and signs of major bile duct obstruction with prominent portal and lobular inflammation. In BDL/SRL group, moderate damage was seen. Tubular injury scores were higher in the BDL subgroups; however, group 3 rats showed considerably fewer lesions in the tubules and interstitium compared to the group 2 rats. In group 2 animals, in the epithelial cells of proximal tubules presented vacuoles and hydropic changes, atrophy and inflammatory cell infiltrate in the medullar interstitium. Conclusions: Sirolimus decreased tubulointerstitial lesions in kidney induced by bile duct ligation in rats. The improve effects of sirolimus on renal morphology can be due to improved liver function or due to direct action on the kidney.en_US
dc.identifier.doi10.1590/S0102-86502010000500004
dc.identifier.endpage406en_US
dc.identifier.issn0102-8650
dc.identifier.issn1678-2674
dc.identifier.issue5en_US
dc.identifier.pmid20877949en_US
dc.identifier.scopus2-s2.0-77957664821en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage401en_US
dc.identifier.urihttps://doi.org/10.1590/S0102-86502010000500004
dc.identifier.urihttps://hdl.handle.net/20.500.12491/6646
dc.identifier.volume25en_US
dc.identifier.wosWOS:000282219500004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorTerzi, Akan
dc.institutionauthorÖztürk, Hayrettin
dc.institutionauthorKükner, Aysel
dc.language.isoenen_US
dc.publisherActa Cirurgica Brasileiraen_US
dc.relation.ispartofActa Cirurgica Brasileiraen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSirolimusen_US
dc.subjectCommon Bile Ducten_US
dc.subjectLigationen_US
dc.subjectLiveren_US
dc.subjectKidneyen_US
dc.subjectRatsen_US
dc.titleEffect of sirolimus on renal injury induced by bile duct ligation in ratsen_US
dc.typeArticleen_US

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