Major ozonated autohemotherapy preconditioning ameliorates kidney ischemia-reperfusion injury

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dc.authorid0000-0003-1470-5952en_US
dc.authorid0000-0003-4154-2052
dc.authorid0000-0003-1888-9322
dc.authorid0000-0001-5400-0012
dc.contributor.authorSancak, Eyüp Burak
dc.contributor.authorTürkön, Hakan
dc.contributor.authorÇukur, Selma
dc.contributor.authorErimşah, Sevilay
dc.contributor.authorAkbaş, Alpaslan
dc.date.accessioned2021-06-23T19:43:55Z
dc.date.available2021-06-23T19:43:55Z
dc.date.issued2016
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractMedical ozone has therapeutic properties as an antimicrobial, anti-inflammatory, modulator of antioxidant defense system. Major ozonated autohemotherapy (MOA) is a new therapeutic approach that is widely used in the treatment of many diseases. The objective of the present study was to determine whether preischemic application of MOA would attenuate renal ischemia-reperfusion injury (IRI) in rabbits. Twenty-four male New Zealand white rabbits were divided into four groups, each including six animals: (1) Sham-operated group, (2) Ozone group (the MOA group without IRI), (3) IR group (60 min ischemia followed by 24 h reperfusion), and (4) IR + MOA group (MOA group). The effects of MOA were examined by use of hematologic and biochemical parameters consisting of neutrophil to lymphocyte ratio (NLR), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), ischemia-modified albumin (IMA), total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI). In addition, the histopathological changes including the tubular brush border loss (TBBL), tubular cast (TC), tubular necrosis (TN), intertubular hemorrhage and congestion (IHC), dilatation of bowman space (DBS), and interstitial inflammatory cells infiltration (IECI) were evaluated. In the IR group, compared to the Sham group, biochemical parameters indicating oxidative stress, NLR, IL-6, TNF-alpha, IMA, TOS, and OSI have increased. MOA reduced inflammation and oxidative stress parameters. Although TAS values have decreased in the IR group and increased in the MOA-pretreated group, no significant changes in TAS values were detected between the IR and MOA groups. The total score was obtained by summing all the scores from morphological kidney damage markers. The total score has increased with IR damage when compared with the Sham group (13.83 +/- 4.30 vs 1.51 +/- 1.71; p = 0.002). But, the total score has decreased significantly after application of MOA (5.01 +/- 1.49; p = 0.002; compared with the IR group). MOA preconditioning is effective in reducing tissue damage induced in kidney ischemia-reperfusion injury. The protective effect of MOA is mediated via reducing inflammatory response and regulating of reactive oxygen species (ROS). Renal histology also showed convincing evidence regarding MOA's protective nature against kidney injury induced renal ischemia-reperfusion. Consequently, MOA might be helpful in protecting the kidneys from IR-induced damage in humans, probably through the anti-inflammatory effect and reducing the total oxidant status.en_US
dc.identifier.doi10.1007/s10753-015-0240-z
dc.identifier.endpage217en_US
dc.identifier.issn0360-3997
dc.identifier.issn1573-2576
dc.identifier.issue1en_US
dc.identifier.pmid26282390en_US
dc.identifier.scopus2-s2.0-84958037479en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage209en_US
dc.identifier.urihttps://doi.org/10.1007/s10753-015-0240-z
dc.identifier.urihttps://hdl.handle.net/20.500.12491/8879
dc.identifier.volume39en_US
dc.identifier.wosWOS:000370083500024en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorÇukur, Selma
dc.institutionauthorErimşah, Sevilay
dc.language.isoenen_US
dc.publisherSpringer/Plenum Publishersen_US
dc.relation.ispartofInflammationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMajor Ozonated Autohemotherapyen_US
dc.subjectRenal Ischemia-Reperfusion Injuryen_US
dc.subjectMedical Ozoneen_US
dc.subjectNeutrophil to Lymphocyte Ratioen_US
dc.subjectTotal Oxidant Statusen_US
dc.titleMajor ozonated autohemotherapy preconditioning ameliorates kidney ischemia-reperfusion injuryen_US
dc.typeArticleen_US

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