Lithospermic acid and ischemia/reperfusion injury of the rat small intestine prevention

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dc.authorid0000-0002-2119-9448en_US
dc.authorid0000-0001-5608-5742
dc.authorid0000-0001-9839-6717
dc.contributor.authorÖztürk, Hülya
dc.contributor.authorTerzi, Elçin Hakan
dc.contributor.authorÖzgen, Ufuk
dc.contributor.authorDuran, Arif
dc.contributor.authorÖztürk, Hayrettin
dc.date.accessioned2021-06-23T19:29:25Z
dc.date.available2021-06-23T19:29:25Z
dc.date.issued2012
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground. Intestinal ischemia and reperfusion (I-R) injury of different causes, including cardiac insufficiency, sepsis, vasodepressant and cardiodepressant drugs, and complications of long-lasting surgery, represents a major clinical problem. Objectives. The purpose of the present study was to investigate whether lithospermic acid (LA) can reduce oxidative stress and histological damage in the rat small bowel subjected to mesenteric I-R injury. Material and Methods. The study was performed on three groups of animals, each composed of 7 rats: the SO (sham operation) group, the I-R/Untreated group and the I-R/LA (I-R plus LA pretreatment) group. Intestinal ischemia for 45 minutes and reperfusion for 60 minutes were applied. Ileum specimens were obtained to determine the tissue level of malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT) and myeloperoxidase (MPO) activities and histological changes. Results. Untreated intestinal I-R resulted in increased tissue MDA and MPO levels and diminished SOD and GPx activities. These changes were found to be almost reversed in the LA treatment group. Histopathologically, the intestinal injury in rats treated with LA was less than the untreated I-R group. Conclusions. Lithospermic acid attenuates mesenteric ischemia reperfusion injury in rat intestines by increasing tissue SOD and GPx activities and decreasing MDA and MPO levels. Lithospermic acid also improves morphological alterations which occurred after periods of reperfusion (Adv Clin Exp Med 2012, 21, 4, 433-439).en_US
dc.identifier.endpage439en_US
dc.identifier.issn1899-5276
dc.identifier.issn2451-2680
dc.identifier.issue4en_US
dc.identifier.pmid23240448en_US
dc.identifier.scopus2-s2.0-84866433133en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage433en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12491/7169
dc.identifier.urihttps://pubmed.ncbi.nlm.nih.gov/23240448/
dc.identifier.volume21en_US
dc.identifier.wosWOS:000311064600003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorÖztürk, Hülya
dc.institutionauthorTerzi, Elçin Hakan
dc.institutionauthorDuran, Arif
dc.institutionauthorÖztürk, Hayrettin
dc.language.isoenen_US
dc.publisherWroclaw Medical Univen_US
dc.relation.ispartofAdvances In Clinical And Experimental Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSmall Bowelen_US
dc.subjectIschemia and Reperfusion Injuryen_US
dc.subjectLithospermic Aciden_US
dc.titleLithospermic acid and ischemia/reperfusion injury of the rat small intestine preventionen_US
dc.typeArticleen_US

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