Silibinin effect on methotrexate-induced hepatotoxicity in rats

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dc.authorid0000-0002-8212-7149en_US
dc.authorid0000-0002-9054-3134en_US
dc.authorid0000-0002-4207-2833en_US
dc.authorid0000-0001-8101-1104en_US
dc.authorid0000-0001-9447-6322en_US
dc.authorid0000-0002-1452-3879en_US
dc.contributor.authorYanaşoğlu, Emine
dc.contributor.authorBüyükavcı, Mustafa
dc.contributor.authorÇetinkaya, Ayhan
dc.contributor.authorTuran, Gupse
dc.contributor.authorKöroğlu, Mehmet
dc.contributor.authorYazar, Hayrullah
dc.contributor.authorBüyükokuroğlu, Mehmet Emin
dc.date.accessioned2023-08-16T08:56:37Z
dc.date.available2023-08-16T08:56:37Z
dc.date.issued2022en_US
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.descriptionSakarya University Scientific Research Project Uniten_US
dc.description.abstractObjective: Hepatotoxicity is one of the major side effects of methotrexate and limits its use. In this study, we investigated the hepatoprotective effect of silibinin and the role of oxidative stress markers and cytokines on high-dose methotrexate-induced hepatotoxicity in rats. Materials and Methods: In this study, rats were randomly divided into 5 groups (n = 7). Methotrexate (20 mg/kg, intraperitoneally) was administered on the first day in all groups except control. Silibinin was injected for 5 days to methotrexate-silibinin25, methotrexate-silibinin50, and methotrexate-silibinin 100 groups at a dose of 25, 50, arid 100 mg/kg/day, respectively. On the sixth day. blood and liver samples were obtained and rats were sacrificed. Serum total antioxidant capacity, total oxidant status, total thiol, native thiol, alanine aminotransferase, aspartate transaminase, bilirubin, albumin, tumor necrosis factor-alpha, and interleukin-10 levels were measured. In addition, a histopathological evaluation of liver tissues was performed. Results: Methotrexate reduced total antioxidant capacity and increased disulfide/total thiol ratio. Histopathologic examination revealed that methotrexate increased hepatic damage and 50 mg/kg/dose of silibinin prevented inflammatory cell infiltration in particular. Conclusion: Our results suggest that silibinin (50 mg/kg/day) may reduce the hepatic damage in rnethotrexate-induced hepatotoxicity in rats by increasing antioxidant capacity.en_US
dc.description.sponsorshipSakarya University Scientific Research Project Unit [2017-40-02-007]en_US
dc.identifier.citationYanaşoğlu, E., Büyükavcı, M., Çetinkaya, A., Turan, G., Köroğlu, M., Yazar, H., & Büyükokuroğlu, M. E. (2022). Silibinin Effect on Methotrexate-Induced Hepatotoxicity in Rats. The Eurasian Journal of Medicine, 54(3), 264.en_US
dc.identifier.doi10.5152/eurasianjmed.2022.20371
dc.identifier.endpage269en_US
dc.identifier.issn1308-8742
dc.identifier.issue3en_US
dc.identifier.pmid35971282en_US
dc.identifier.scopus2-s2.0-85140204382en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage264en_US
dc.identifier.trdizinid1167043en_US
dc.identifier.urihttp://dx.doi.org/10.5152/eurasianjmed.2022.20371
dc.identifier.urihttps://hdl.handle.net/20.500.12491/11543
dc.identifier.volume54en_US
dc.identifier.wosWOS:000891602000011en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorÇetinkaya, Ayhan
dc.language.isoenen_US
dc.publisherAvesen_US
dc.relation.ispartofEurasian Journal of Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMethotrexateen_US
dc.subjectHepatotoxicityen_US
dc.subjectSilibininen_US
dc.subjectOxidative Stressen_US
dc.subjectThiol/Disulfideen_US
dc.subjectMilk Thistleen_US
dc.titleSilibinin effect on methotrexate-induced hepatotoxicity in ratsen_US
dc.typeArticleen_US

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