Prevention of torsion-induced testicular injury by rhodiola rosea

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dc.contributor.authorÜyetürk, Uğur
dc.contributor.authorTerzi, E. Hakan
dc.contributor.authorGücük, Adnan
dc.contributor.authorKemahlı, Eray
dc.contributor.authorÖztürk, Hayrettin
dc.contributor.authorTosun, Mehmet
dc.date.accessioned2021-06-23T19:34:29Z
dc.date.available2021-06-23T19:34:29Z
dc.date.issued2013
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractOBJECTIVE To evaluate the efficacy of Rhodiola rosea (R. rose) extract in terms of preventing tissue injury induced by testicular torsion and subsequent ischemia/reperfusion (I/R). METHODS Twenty-one Wistar albino male rats were divided into 3 groups: group 1 = control group, group 2 = I/R group, and group 3 = I/R + extract group. After 2 hours of ischemia and 4 hours of reperfusion, testes were removed and evaluated histologically by hematoxylin and eosin staining. Apoptosis in spermatogonial cells of seminiferous tubules was determined by transferase biotin-2'-deoxyuridine, 5'-triphosphate nick end labeling (TUNEL). To assess oxidative damage, serum malondialdehyde (MDA) and glutathione (GSH) levels were measured. RESULTS Median MDA and GSH levels were, respectively, 12 +/- 3 pmol/mL and 24.8 +/- 3.8 mu M in group 1, 38 +/- 11 pmol/mL and 10.3 +/- 1.7 mu M in group 2, and 19 +/- 5 pmol/mL and 17.6 +/- 1.3 mu M in group 3 (P <.001 and P <.001, respectively). Median MDA levels, apoptotic cell density, and histopathologic scoring were significantly lower in groups 1 and 3 compared to group 2 (P <.017 for all). Median GSH levels were higher in groups 1 and 3 compared to group 2 (P <.017). CONCLUSION R. rosea extract was shown to have partially preventive effects on testicular injury induced by torsion in this rat model. The mechanism by which R. rosea extract cause these effects merits further investigation. UROLOGY 82: 254.e1-254.e6, 2013. (C) 2013 Elsevier Inc.en_US
dc.identifier.doi10.1016/j.urology.2013.04.018
dc.identifier.issn0090-4295
dc.identifier.issn1527-9995
dc.identifier.issue1en_US
dc.identifier.pmid23806408en_US
dc.identifier.scopus2-s2.0-84879509301en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.urology.2013.04.018
dc.identifier.urihttps://hdl.handle.net/20.500.12491/7527
dc.identifier.volume82en_US
dc.identifier.wosWOS:000321036200069en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorÜyetürk, Uğur
dc.institutionauthorTerzi, E. Hakan
dc.institutionauthorGücük, Adnan
dc.institutionauthorKemahlı, Eray
dc.institutionauthorÖztürk, Hayrettin
dc.institutionauthorTosun, Mehmet
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofUrologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titlePrevention of torsion-induced testicular injury by rhodiola roseaen_US
dc.typeArticleen_US

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