Leptin in corneas from keratoconus and infectious keratitis patients

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dc.authorid0000-0001-5387-2628
dc.authorid0000-0003-2191-9297
dc.authorid0000-0003-0887-6974
dc.authorid0000-0003-1364-4684
dc.contributor.authorAydemir, Orhan
dc.contributor.authorNazıroğlu, Mustafa
dc.contributor.authorÇolakoğlu, Neriman
dc.contributor.authorYılmaz, Turgut
dc.contributor.authorKükner, Aysel
dc.contributor.authorKükner, A. Şahap
dc.date.accessioned2021-06-23T19:18:11Z
dc.date.available2021-06-23T19:18:11Z
dc.date.issued2005
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü
dc.description.abstractPurpose: Leptin is produced primarily by adipose tissue. More recent studies have shown extra sites of leptin production in physiologic and ill human tissues. However, whether leptin originates from human corneas in infectious keratitis and keratoconus is not known. The aim of this study was to demonstrate and quantitate leptin expression in corneas with infectious keratitis and keratoconus and make comparisons to control corneas. Methods: We examined the immunohistochemical staining of leptin in nine corneas surgically excised from patients with infectious keratitis (3 patients), keratoconus (3 patients), and donor corneas (3 patients). Results: The results were analyzed using a semi quantitative scoring system of mild, moderate, and strong. Cells of the infectious keratitis group had the strongest leptin staining intensity, the control group had moderate, and the keratoconus group had mild staining intensity. The more vascular corneas in the infectious keratitis group were also associated with the greatest leptin staining. Conclusions: Our findings indicate that leptin expression was present in all three sources of corneas (infectious keratitis, keratoconus, and normal control). Quantitative scoring would imply it may play a role in infectious keratitis, although further experiments are necessary to establish any causal relationship.en_US
dc.identifier.doi10.1089/jop.2005.21.382
dc.identifier.endpage387en_US
dc.identifier.issn1080-7683
dc.identifier.issn1557-7732
dc.identifier.issue5en_US
dc.identifier.pmid16245964en_US
dc.identifier.scopus2-s2.0-27544477731en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage382en_US
dc.identifier.urihttps://doi.org/10.1089/jop.2005.21.382
dc.identifier.urihttps://hdl.handle.net/20.500.12491/5665
dc.identifier.volume21en_US
dc.identifier.wosWOS:000232969500004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKükner, Aysel
dc.institutionauthorKükner, A. Şahap
dc.language.isoenen_US
dc.publisherMary Ann Liebert, Incen_US
dc.relation.ispartofJournal Of Ocular Pharmacology And Therapeuticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCorneasen_US
dc.subjectLeptin
dc.subjectKeratoconus
dc.subjectInfectious Keratitis
dc.titleLeptin in corneas from keratoconus and infectious keratitis patientsen_US
dc.typeArticleen_US

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