The potential therapeutic effects of agmatine, methylprednisolone, and rapamycin on experimental spinal cord injury

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dc.authorid0000-0002-8317-7092en_US
dc.authorid0000-0001-5387-2628en_US
dc.authorid0000-0003-0344-6246en_US
dc.authorid0000-0002-9313-2920en_US
dc.contributor.authorFırat, Tülin
dc.contributor.authorKükner, Aysel
dc.contributor.authorAytürk, Nilüfer
dc.contributor.authorGezici, Ali Rıza
dc.contributor.authorSerin, Erdinç
dc.contributor.authorÖzoğul, Candan
dc.date.accessioned2023-07-19T13:07:39Z
dc.date.available2023-07-19T13:07:39Z
dc.date.issued2021en_US
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.descriptionThe authors thank Erdem Ferdi Firat for his assistance during the animal studies. This research was financially supported by Abant Izzet Baysal University (project no: BAP 2009.08.01.305). The authors declare that they have no competing interests.en_US
dc.description.abstractObjective: In spinal cord injury (SCI), the primary mechanical damage leads to a neuroinflammatory response and the secondary neuronal injury occurs in response to the release of reactive oxygen species (ROS). In addition to the suppression of inflammation, autophagy plays a significant role in the survival of neurons during secondary SCI. The present study aimed to examine the anti-inflammatory and autophagic effects of agmatine and rapamycin in SCI and to compare the results with methylprednisolone (MP) used in the clinic. Materials and Methods: In this animal-based experimental study, thirty adult male Sprague-Dawley rats were randomly divided into five groups as sham-control, injury, injury-FMP, injury+rapamycin, injury+agmatine groups. SCI was induced by compressing the T7-8-9 segments of the spinal cord, using an aneurysm clip for one minute, and then rats were treated daily for 7 days. Seven days post-treatment, damaged spinal cord tissues of sacrificed rats were collected for microscopic and biochemical examinations using histopathologic and transmission electron microscope (TEM) scores. Malondialdehyde (MDA) and glutathione peroxidase (GPx) levels were spectrophotometrically measured. Results: The results of this study showed that the damaged area was smaller in the rapamycin group when compared to the MP group. Many autophagic vacuoles and macrophages were observed in the rapamycin group. Degeneration of axon, myelin, and wide edema was observed in SCI by electron microscopic observations. Fragmented myelin lamellae and contracted axons were also noted. While MDA and GPx levels were increased in the injury group, MDA levels were significantly decreased in the agmatine and MP groups, and GPx levels were decreased in the rapamycin group. Conclusion: The results of our study confirmed that rapamycin and agmatine can be an effective treatment for secondary injury of SCI.en_US
dc.description.sponsorshipAbant Izzet Baysal University [BAP 2009.08.01.305]en_US
dc.identifier.citationFirat, T., Kukner, A., Ayturk, N., Gezici, A. R., Serin, E., Ozogul, C., & Tore, F. (2021). The potential therapeutic effects of agmatine, methylprednisolone, and rapamycin on experimental spinal cord injury. Cell Journal (Yakhteh), 23(6), 701.en_US
dc.identifier.doi10.22074/cellj.2021.7198
dc.identifier.endpage707en_US
dc.identifier.issn2228-5806
dc.identifier.issn2228-5814
dc.identifier.issue6en_US
dc.identifier.pmid34939764en_US
dc.identifier.scopus2-s2.0-85121049317en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage701en_US
dc.identifier.urihttp://dx.doi.org/10.22074/cellj.2021.7198
dc.identifier.urihttps://hdl.handle.net/20.500.12491/11315
dc.identifier.volume23en_US
dc.identifier.wosWOS:000728393500013en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorFırat, Tülin
dc.institutionauthorGezici, Ali Rıza
dc.language.isotren_US
dc.publisherRoyan Instituteen_US
dc.relation.ispartofCell Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAgmatineen_US
dc.subjectMethylprednisoloneen_US
dc.subjectRapamycinen_US
dc.subjectPromotes Locomotor Recoveryen_US
dc.subjectIschemia-Reperfusion Injuryen_US
dc.subjectOxidative Stressen_US
dc.titleThe potential therapeutic effects of agmatine, methylprednisolone, and rapamycin on experimental spinal cord injuryen_US
dc.typeArticleen_US

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