The effect of intraperitoneal paclitaxel administration on colonic anastomosis

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dc.authorid0000-0001-7069-0623en_US
dc.authorid0000-0001-6990-185X
dc.authorid0000-0002-0317-7181
dc.contributor.authorArıkan, A. Yüksel
dc.contributor.authorGünal, Ömer
dc.contributor.authorPehlivan, Mevlüt
dc.contributor.authorAlper, Murat
dc.date.accessioned2021-06-23T19:17:18Z
dc.date.available2021-06-23T19:17:18Z
dc.date.issued2000
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground/Aims: The effect of intraperitoneal administration of chemotherapeutic agents on colonic anastomosis are still under investigation. In this study the effects of intraperitoneally administered paclitaxel on rat colonic anastomosis was investigated. Methodology: After colonic anastomosis, 3mL of isotonic saline was administered intraperitoneally to rats in control group (Group 1, n = 20). The study group (Group 2, n = 20), paclitaxel 3 mg/kg diluted with isotonic saline was administered intraperitoneally after colonic anastomosis. Rats were sacrificed on 14th day and mean body weight, mean anastomosis bursting pressure and the histopathology of the anastomosis site of the two groups were compared. Results: Mean body weight was approximately the same with the preoperative values at 14th day in both groups. Anastomosis bursting pressure in paclitaxel group (127 +/- 3mm Hg) was found to be similar to control group (133 +/- 5mm Hg) (P > 0.05). Mucosal layer formation in the anastomosis line was complete on the 14th day in both groups. Conclusions: As a result intraperitoneal paclitaxel administration was found to be safe as it did not reduce the anastomotic strength and not delay wound healing.en_US
dc.identifier.endpage1276en_US
dc.identifier.issn0172-6390
dc.identifier.issue35en_US
dc.identifier.pmid11100331en_US
dc.identifier.scopus2-s2.0-0033773679en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage1273en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12491/5347
dc.identifier.volume47en_US
dc.identifier.wosWOS:000165363700027en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorArıkan, A. Yüksel
dc.institutionauthorGünal, Ömer
dc.institutionauthorPehlivan, Mevlüt
dc.institutionauthorAlper, Murat
dc.language.isoenen_US
dc.publisherH G E Update Medical Publ Ltd.en_US
dc.relation.ispartofHepato-Gastroenterologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPaclitaxelen_US
dc.subjectColonic Anastomosisen_US
dc.titleThe effect of intraperitoneal paclitaxel administration on colonic anastomosisen_US
dc.typeArticleen_US

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Cerrahi Tıp Bilimleri Bölümü Koleksiyonu
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