The effect of intraperitoneal paclitaxel administration on colonic anastomosis
Küçük Resim Yok
Tarih
2000
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
H G E Update Medical Publ Ltd.
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background/Aims: The effect of intraperitoneal administration of chemotherapeutic agents on colonic anastomosis are still under investigation. In this study the effects of intraperitoneally administered paclitaxel on rat colonic anastomosis was investigated. Methodology: After colonic anastomosis, 3mL of isotonic saline was administered intraperitoneally to rats in control group (Group 1, n = 20). The study group (Group 2, n = 20), paclitaxel 3 mg/kg diluted with isotonic saline was administered intraperitoneally after colonic anastomosis. Rats were sacrificed on 14th day and mean body weight, mean anastomosis bursting pressure and the histopathology of the anastomosis site of the two groups were compared. Results: Mean body weight was approximately the same with the preoperative values at 14th day in both groups. Anastomosis bursting pressure in paclitaxel group (127 +/- 3mm Hg) was found to be similar to control group (133 +/- 5mm Hg) (P > 0.05). Mucosal layer formation in the anastomosis line was complete on the 14th day in both groups. Conclusions: As a result intraperitoneal paclitaxel administration was found to be safe as it did not reduce the anastomotic strength and not delay wound healing.
Açıklama
Anahtar Kelimeler
Paclitaxel, Colonic Anastomosis
Kaynak
Hepato-Gastroenterology
WoS Q Değeri
Q2
Scopus Q Değeri
N/A
Cilt
47
Sayı
35
