Contribution of (18)Fluorodeoxyglucose positron emission tomography uptake and TTF-1 expression in the evaluation of the EGFR mutation in patients with lung adenocarcinoma

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dc.contributor.authorKanmaz, Zehra Dilek
dc.contributor.authorAras, Gülfidan
dc.contributor.authorTuncay, Esin
dc.contributor.authorBahadır, Ayşe
dc.contributor.authorKocatürk, Celalettin
dc.contributor.authorYaşar, Zehra Aşuk
dc.date.accessioned2021-06-23T19:44:36Z
dc.date.available2021-06-23T19:44:36Z
dc.date.issued2016
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractAIM: The aim of this study is to evaluate the diagnostic value of PET-CT scan for the prediction of EGFR mutation status and the contribution of TTF-1 expression to PET-CT scan. METHODS: We retrospectively studied 218 cases with a diagnosis of pulmonary adenocarcinoma between 2012-2014 which underwent EGFR analysis, TTF-1 and PET-CT before treatment. RESULTS: The EGFR mutation was present in 28.9% (n = 63) of cases. TTF-1 positivity was 66.9% (n = 105). Standardized uptake value (SUV max) was 16.7 +/- 6.8 in EGFR mutant type, 13.8 +/- 7.6 in cases having no EGFR mutations. According to our evaluations, high SUVmax is positively correlated with EGFR mutation status. TTF-1 expression in multivariate analysis strengthens the accuracy of detecting an EGFR mutation. CONCLUSION: PET-CT FDG uptake may, together with TTF-1 expression, help diagnosis in lung adenocarcinoma cases when evaluating for EGFR mutation status.en_US
dc.identifier.doi10.3233/CBM-160588
dc.identifier.endpage498en_US
dc.identifier.issn1574-0153
dc.identifier.issn1875-8592
dc.identifier.issue3en_US
dc.identifier.pmid27062706en_US
dc.identifier.scopus2-s2.0-84964200296en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage489en_US
dc.identifier.urihttps://doi.org/10.3233/CBM-160588
dc.identifier.urihttps://hdl.handle.net/20.500.12491/9012
dc.identifier.volume16en_US
dc.identifier.wosWOS:000374182100022en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorYaşar, Zehra Aşuk
dc.language.isoenen_US
dc.publisherIos Pressen_US
dc.relation.ispartofCancer Biomarkersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLung Canceren_US
dc.subjectEGFRen_US
dc.subjectTTF-1en_US
dc.titleContribution of (18)Fluorodeoxyglucose positron emission tomography uptake and TTF-1 expression in the evaluation of the EGFR mutation in patients with lung adenocarcinomaen_US
dc.typeArticleen_US

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