Contribution of (18)Fluorodeoxyglucose positron emission tomography uptake and TTF-1 expression in the evaluation of the EGFR mutation in patients with lung adenocarcinoma
Küçük Resim Yok
Tarih
2016
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Ios Press
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
AIM: The aim of this study is to evaluate the diagnostic value of PET-CT scan for the prediction of EGFR mutation status and the contribution of TTF-1 expression to PET-CT scan. METHODS: We retrospectively studied 218 cases with a diagnosis of pulmonary adenocarcinoma between 2012-2014 which underwent EGFR analysis, TTF-1 and PET-CT before treatment. RESULTS: The EGFR mutation was present in 28.9% (n = 63) of cases. TTF-1 positivity was 66.9% (n = 105). Standardized uptake value (SUV max) was 16.7 +/- 6.8 in EGFR mutant type, 13.8 +/- 7.6 in cases having no EGFR mutations. According to our evaluations, high SUVmax is positively correlated with EGFR mutation status. TTF-1 expression in multivariate analysis strengthens the accuracy of detecting an EGFR mutation. CONCLUSION: PET-CT FDG uptake may, together with TTF-1 expression, help diagnosis in lung adenocarcinoma cases when evaluating for EGFR mutation status.
Açıklama
Anahtar Kelimeler
Lung Cancer, EGFR, TTF-1
Kaynak
Cancer Biomarkers
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
16
Sayı
3
