Neuregulin-4 is associated with plasma glucose and increased risk of type 2 diabetes mellitus

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dc.authorid0000-0002-7006-3125en_US
dc.authorid0000-0001-7306-5233en_US
dc.authorid0000-0003-4419-409X
dc.authorid0000-0002-7821-8275
dc.authorid0000-0003-4201-9757
dc.authorid0000-0002-7422-1442
dc.contributor.authorKoçak, Mehmet Zahid
dc.contributor.authorAktaş, Gülali
dc.contributor.authorErkuş, Edip
dc.contributor.authorYis, Özgür Mehmet
dc.contributor.authorDuman, Tuba Taslamacıoğlu
dc.contributor.authorAtak Tel, Burçin Meryem
dc.contributor.authorHaluk, Şavlı
dc.date.accessioned2021-06-23T19:50:40Z
dc.date.available2021-06-23T19:50:40Z
dc.date.issued2019
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractBACKGROUND: Neuregulin-4 is a cytokine with many functions and is primarily produced by fat tissue. AIM OF THE STUDY: The aim of the study was to observe the relationship between serum neuregulin-4 levels and diabetes regulation in type 2 diabetes mellitus (T2DM), and to compare neuregulin-4 levels of diabetic subjects with those in healthy controls. METHODS: Patients with T2DM were included to the study. Healthy subjects were enrolled as controls. Subjects with T2DM with glycated haemoglobin (HbA1c) <7% were classed as well controlled and those with HbA1c >= 7% were classed as poorly controlled. Neuregulin-4 levels of the study and control groups were compared. RESULTS: The neuregulin-4 levels of the poorly controlled T2DM, well-controlled T2DM and control groups were significantly different (p = 0.005). Neuregulin-4 was significantly correlated with fasting plasma glucose (r = 0.247, p = 0.002) but not with HbA1c. In a regression analysis model, 0.1 point elevation in neuregulin-4 levels increased the rate of existence of T2DM 4.4-fold (odds ratio 4.4, 95% confidence interval 1.26-15.1; p = 0.02). CONCLUSION: Neuregulin-4 is significantly increased in patients with T2DM compared with control subjects, which means that it could be a marker of T2DM. Since neuregulin-4 was correlated with fasting glucose, we suggest that elevated neuregulin-4 could predict poor control in T2DM for short periods when HbA1c is not useful. Moreover, one unit elevation in neuregulin-4 (0.1 ng/ml) increases the rate of existence of T2DM 4.4-fold, independently from other variables.en_US
dc.identifier.doi10.4414/smw.2019.20139
dc.identifier.issn1424-7860
dc.identifier.issn1424-3997
dc.identifier.pmid31656034en_US
dc.identifier.scopus2-s2.0-85074150471en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.4414/smw.2019.20139
dc.identifier.urihttps://hdl.handle.net/20.500.12491/9837
dc.identifier.volume149en_US
dc.identifier.wosWOS:000492841300001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorAktaş, Gülali
dc.institutionauthorYis, Özgür Mehmet
dc.institutionauthorDuman, Tuba Taslamacıoğlu
dc.institutionauthorKoçak, Mehmet Zahid
dc.institutionauthorHaluk, Şavlı
dc.language.isoenen_US
dc.publisherE M H Swiss Medical Publishers Ltden_US
dc.relation.ispartofSwiss Medical Weeklyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectNeuregulin-4en_US
dc.subjectType 2 Diabetes Mellitusen_US
dc.subjectFasting Blood Glucoseen_US
dc.subjectDiabetes Regulationen_US
dc.titleNeuregulin-4 is associated with plasma glucose and increased risk of type 2 diabetes mellitusen_US
dc.typeArticleen_US

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