Intraperitoneal administration of single dose type I collagen or low dose melatonin to prevent intraperitoneal adhesion formation: A comparative study

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dc.authorid0000-0002-4060-3354en_US
dc.authorid0000-0002-8929-6973
dc.authorid0000-0002-4060-3354
dc.authorid0000-0001-7965-6229
dc.contributor.authorKoç, Önder
dc.contributor.authorDuran, Bülent
dc.contributor.authorTopçuoğlu, Ata
dc.contributor.authorBuğdaycı, Güler
dc.contributor.authorYılmaz, Fahri
dc.contributor.authorDönmez, Melahat
dc.date.accessioned2021-06-23T19:26:09Z
dc.date.available2021-06-23T19:26:09Z
dc.date.issued2009
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractObjective: To compare the prevention of adhesion formation by type I collagen or melatonin solutions in the rat model. Study design: A total of 40 female Wistar albino rats were randomly assigned to four groups-type I collagen, melatonin, vehicle control and sham groups. Following midline laparotomy, a standard injury was made on the right uterine horn using bipolar cautery. The animals in the sham group underwent midline laparatomy only. One milliliter of type I collagen, melatonin or vehicle control was instilled onto the injured area immediately before abdominal closure. Fourteen days after the surgery, the type and extent of adhesion formation as well as the uterine horn tissue superoxide dismutase (SOD) and catalase (CAT) activity, and malondialdehyde (MDA) levels were measured. Results: Both the type and extent of adhesion formation were significantly lower in the type I collagen and melatonin groups compared to the control group. The tissue SOD and CAT activity was significantly higher, and MDA levels were significantly lower in the type I collagen and melatonin groups compared to the control group. Conclusion: Intraperitoneal administration of type I collagen or low dose melatonin solution onto the injured areas may be an attractive adjuvant to reduce postoperative adhesion formation. (C) 2009 Elsevier Ireland Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.ejogrb.2009.05.019
dc.identifier.endpage213en_US
dc.identifier.issn0301-2115
dc.identifier.issue2en_US
dc.identifier.pmid19523743en_US
dc.identifier.scopus2-s2.0-67650082940en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage209en_US
dc.identifier.urihttps://doi.org/10.1016/j.ejogrb.2009.05.019
dc.identifier.urihttps://hdl.handle.net/20.500.12491/6436
dc.identifier.volume145en_US
dc.identifier.wosWOS:000268791600018en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKoç, Önder
dc.institutionauthorDuran, Bülent
dc.institutionauthorTopçuoğlu, Ata
dc.institutionauthorBuğdaycı, Güler
dc.institutionauthorBuğdaycı, Güler
dc.institutionauthorYılmaz, Fahri
dc.institutionauthorDönmez, Melahat
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofEuropean Journal Of Obstetrics & Gynecology And Reproductive Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAdhesionen_US
dc.subjectIntraperitonealen_US
dc.subjectType I Collagenen_US
dc.subjectMelatoninen_US
dc.subjectRaten_US
dc.titleIntraperitoneal administration of single dose type I collagen or low dose melatonin to prevent intraperitoneal adhesion formation: A comparative studyen_US
dc.typeArticleen_US

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