Contractile responses of rabbit bladder neck to adrenaline, acetylcholine and papaverine after doxazosin treatment
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Dosyalar
Tarih
2007
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
It has been demonstrated that long-term administration of doxazosin, an alpha 1 adrenoceptor antagonist, causes an up-regulation in the expression of alpha 1 adrenoceptor subtype mRNAs in the rat genitourinary tract. The aim of this study is to determine whether this up-regulation does have any effect on contractile response of rabbit bladder neck to adrenaline, acethylcholine and papaverin after long-term doxazosin treatment. Fourteen rabbits, treated with doxazosin 3 mg/kg/day p.o for 6 months, and were fed with a diet of standard laboratory rabbit chow (100 g/kg/day). Ten rabbits received the same amount of regular chow but no drug. Contractile responses of rabbit bladder neck to adrenaline acethylcholine and papaverine were measured.
Açıklama
Anahtar Kelimeler
Acetylcholine, Adrenaline, Bladder neck, Contraction, Papaverine
Kaynak
International Urology And Nephrology
WoS Q Değeri
Q4
Scopus Q Değeri
Q2
Cilt
39
Sayı
1
