Alleviation of kidney damage induced by unilateral ureter obstruction in rats by rhodiola rosea

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dc.authorid0000-0002-8212-7149en_US
dc.authorid0000-0003-1698-8263en_US
dc.authorid0000-0001-7858-0672
dc.contributor.authorÜyetürk, Uğur
dc.contributor.authorTerzi, E. Hakan
dc.contributor.authorKemahlı, Eray
dc.contributor.authorGücük, Adnan
dc.contributor.authorTosun, Mehmet
dc.contributor.authorÇetinkaya, Ayhan
dc.date.accessioned2021-06-23T19:34:13Z
dc.date.available2021-06-23T19:34:13Z
dc.date.issued2013
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractPurpose: To evaluate the efficacy of Rhodiola rosea extract in terms of alleviating the renal damage induced by unilateral ureter obstruction (UUO) in rats. Material and Methods: Thirty Wistar albino male rats were divided into five groups: (I) Control, (II) UUO 7 days, (III) UUO 7 days+extract,(IV) UUO 14 days, and (V) UUO 14 days+extract. Seven or 14 days after the initiation of the experimental procedure, the left kidneys of rats in all five groups were removed for histological examination, and their blood was drawn for biochemical measurements. Result: Median malondialdehyde (MDA) and glutathione peroxidase (GPx) levels were, respectively, 39.4 (5.04) nmol/mL and 25.8 (8.01) nmol/minute/mL in group I, 77.9 (12.38) nmol/mL and 5.8 (1.95) nmol/minute/mL in group II, 48.7 (12.1) nmol/mL and 9.1 (2.3) nmol/minute/mL in group III, 58.5 (23.83) nmol/mL and 8.4 (2.1) nmol/minute/mL in group IV, and 44.8 (4.97) nmol/mL and 13.8 (3.73) nmol/minute/mL in group V. There was a statistically significant difference among the groups in terms of MDA and GPx levels (p<0.05 for both). The median numbers of apoptotic cells were 1 (1), 8 (2.25), 3 (1.25), 23.5 (9), and 7 (I) in groups I, II, III, IV, and V, respectively. There was a statistically siginificant difference among the groups in terms of apoptotic cell number (p<0.05). Conclusion:R. rosea extract was shown to alleviate the renal damage induced by UUO through its antioxidant effects. The mechanism by which R. rosea extract causes these effects merits further investigation.en_US
dc.identifier.doi10.1089/end.2013.0319
dc.identifier.endpage1276en_US
dc.identifier.issn0892-7790
dc.identifier.issn1557-900X
dc.identifier.issue10en_US
dc.identifier.pmid23806024en_US
dc.identifier.startpage1272en_US
dc.identifier.urihttps://doi.org/10.1089/end.2013.0319
dc.identifier.urihttps://hdl.handle.net/20.500.12491/7432
dc.identifier.urihttps://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC3787484&blobtype=pdf
dc.identifier.volume27en_US
dc.identifier.wosWOS:000325147400017en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorÜyeturk, Uğur
dc.institutionauthorTerzi, E. Hakan
dc.institutionauthorKemahlı, Eray
dc.institutionauthorGücük, Adnan
dc.institutionauthorTosun, Mehmet
dc.institutionauthorÇetinkaya, Ayhan
dc.language.isoenen_US
dc.publisherMary Ann Liebert, Incen_US
dc.relation.ispartofJournal Of Endourologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleAlleviation of kidney damage induced by unilateral ureter obstruction in rats by rhodiola roseaen_US
dc.typeArticleen_US

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