Protective effects of chronic melatonin treatment against renal injury in streptozotocin-induced diabetic rats

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dc.authorid0000-0002-5800-3306
dc.authorid0000-0003-1937-9244
dc.authorid0000-0001-7511-7105
dc.authorid0000-0003-2339-5669
dc.authorid0000-0003-1691-618X
dc.contributor.authorÇam, Meryem
dc.contributor.authorYavuz, Özlem
dc.contributor.authorGüven, Aysel
dc.contributor.authorErcan, Feriha
dc.contributor.authorBukan, Neslihan
dc.contributor.authorÜstündağ, Nil
dc.date.accessioned2021-06-23T19:17:32Z
dc.date.available2021-06-23T19:17:32Z
dc.date.issued2003
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü
dc.description.abstractThe aim of this study was to investigate the effects of melatonin as an antioxidant, on prevention and treatment of streptozotocin (STZ)induced diabetic renal injury in rats. Male Wistar rats were divided into four groups: ( 1) untreated, ( 2) melatonin-treated, ( 3) untreated diabetic (UD), ( 4) melatonin-treated diabetic ( MD). Experimental diabetes was induced by single dose ( 60 mg/kg, i.p.) STZ injection. For 3 days prior to administration of STZ, melatonin was injected ( 200 mug/kg/day, i.p.); these injections were continued until the end of the study ( 4 weeks). Malondialdehyde (MDA) levels as a marker of lipid peroxidation were significantly increased in the renal homogenates of UD animals and decreased after melatonin administration. The activity of the antioxidative enzyme glutathione peroxidase (GSH-Px) was significantly reduced in UD rats. Melatonin treatment reversed STZ-induced reduction of GSH-Px activity without having an effect on blood glucose. Upon histopathological examination, it was observed that the melatonin treatment prevented the renal morphological damage caused by diabetes. Upon immunohistochemical investigation, glomerular anti-laminin beta1 staining decreased in MD rats. Additionally, no tubular anti-IGF-1 staining was observed in melatonin-treated rats. In conclusion, chronically administered melatonin reduced renal injury in STZ-induced diabetic rats and thus it may provide a useful therapeutic option in humans to reduce oxidative stress and the associated renal injury in patients with diabetes mellitus.en_US
dc.identifier.doi10.1034/j.1600-079X.2003.00082.x
dc.identifier.endpage220en_US
dc.identifier.issn0742-3098
dc.identifier.issue3en_US
dc.identifier.pmid12932206en_US
dc.identifier.scopus2-s2.0-0042412173en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage212en_US
dc.identifier.urihttps://doi.org/10.1034/j.1600-079X.2003.00082.x
dc.identifier.urihttps://hdl.handle.net/20.500.12491/5451
dc.identifier.volume35en_US
dc.identifier.wosWOS:000185114600011en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorÜstündağ, Nil
dc.institutionauthorYavuz, Özlem
dc.language.isoenen_US
dc.publisherBlackwell Munksgaarden_US
dc.relation.ispartofJournal Of Pineal Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDiabetic Renal Injuryen_US
dc.subjectGlutathione Peroxidaseen_US
dc.subjectImmunohistochemistryen_US
dc.subjectMalondialdehydeen_US
dc.subjectMelatoninen_US
dc.subjectOxidative Stressen_US
dc.subjectStreptozotocinen_US
dc.titleProtective effects of chronic melatonin treatment against renal injury in streptozotocin-induced diabetic ratsen_US
dc.typeArticleen_US

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