Association of extent and aggressiveness of inflammation with serum PSA levels and PSA density in asymptomatic patients

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dc.authorid0000-0001-8688-4772en_US
dc.authorid0000-0002-5830-5961
dc.authorid0000-0001-8688-4772
dc.authorid0000-0003-0580-2144
dc.contributor.authorKandıralı, Engin
dc.contributor.authorBoran, Çetin
dc.contributor.authorSerin, Erdinç
dc.contributor.authorSemerciöz, Atilla
dc.contributor.authorMetin, Ahmet
dc.date.accessioned2021-06-23T19:19:52Z
dc.date.available2021-06-23T19:19:52Z
dc.date.issued2007
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractOBJECTIVES The relationship between serum prostate-specific antigen (PSA) levels and histologic prostatic inflammation is controversial. Previous studies were performed using either the intensity or extent of inflammation for grading, with a relatively lower number of specimens. In our study, the inflammation was categorized more profoundly, using both the intensity and the extent of inflammation, to determine the influence of prostatic inflammation on serum PSA levels, percent free PSA (%fPSA), and PSA density (PSAD). METHODS The study included 115 patients who underwent transrectal ultrasound-guided prostate biopsy. To categorize the inflammation, a grading method that included the intensity and extent of inflammation was used. The extent and aggressiveness of inflammation were analyzed. The patients were divided into groups using five grades for the extent and four grades for the aggressiveness of inflammation. The serum PSA Levels, fPSA levels, %fPSA, and PSAD in each group were compared. RESULTS The extent of inflammation grade correlated positively with the serum PSA level (r = 0.423, P <0.001) and PSAD (r = 0.319, P = 0.001). However, a negative correlation was found between the extent of inflammation grade and %fPSA (r = -0.268, P = 0.015). The aggressiveness of inflammation grade correlated positively with the serum PSA level (r = 0.386, P <0.001) and PSAD (r = 0.341, P = 0.001) and negatively with %fPSA (r = -0.289, P = 0.03). CONCLUSIONS If the elevation of serum PSA is thought to be caused by histologic inflammation, it might prevent unnecessary repeated biopsies.en_US
dc.identifier.doi10.1016/j.urology.2007.06.1102
dc.identifier.endpage747en_US
dc.identifier.issn0090-4295
dc.identifier.issue4en_US
dc.identifier.pmid17991548en_US
dc.identifier.scopus2-s2.0-35648936434en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage743en_US
dc.identifier.urihttps://doi.org/10.1016/j.urology.2007.06.1102
dc.identifier.urihttps://hdl.handle.net/20.500.12491/6019
dc.identifier.volume70en_US
dc.identifier.wosWOS:000251145400026en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKandıralı, Engin
dc.institutionauthorBoran, Çetin
dc.institutionauthorSerin, Erdinç
dc.institutionauthorSemerciöz, Atilla
dc.institutionauthorMetin, Ahmet
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofUrologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAsymptomatic Patientsen_US
dc.titleAssociation of extent and aggressiveness of inflammation with serum PSA levels and PSA density in asymptomatic patientsen_US
dc.typeArticleen_US

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