Components of the alternative complement pathway in patients with psoriasis

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dc.authorid0000-0002-4060-3354en_US
dc.authorid0000-0001-9947-7690
dc.contributor.authorŞereflican, Betül
dc.contributor.authorBuğdaycı, Güler
dc.date.accessioned2021-06-23T19:49:10Z
dc.date.available2021-06-23T19:49:10Z
dc.date.issued2017
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractIntroduction: Psoriasis is a chronic inflammatory skin disease. Adipose tissue plays important roles in the events that regulate body metabolism. This study determined the levels of complement 3 (C-3), acylation-stimulating protein (ASP), and adipsin, which take part in the alternate complement pathway, and are synthesized in and secreted by adipose tissue. Methods: Thirty-two patients with psoriasis were matched with 22 controls in terms of age, sex, body mass index, and lipid profiles. Serum C-3, ASP, and adipsin levels were measured in both groups. Results: The serum C-3 level was higher and ASP and adipsin levels were lower in the patient group, but these differences were not significant (p = 0.708, p = 0.628, and p = 0.218, respectively). ASP and adipsin levels were correlated positively in patients with psoriasis (p = 0.029). Conclusion: To our knowledge, this study is the first to evaluate ASP and adipsin levels in patients with psoriasis. The roles of ASP and adipsin in the etiopathogenesis of psoriasis are unclear. Although not statistically significant, the lower ASP and adipsin levels in the patient group suggest a potential anti-inflammatory role of these proteins in psoriasis. Further studies should examine the relationships between ASP/adipsin and psoriasis.en_US
dc.identifier.doi10.15570/actaapa.2017.11
dc.identifier.endpage40en_US
dc.identifier.issn1318-4458
dc.identifier.issn1581-2979
dc.identifier.issue2en_US
dc.identifier.pmid28632884en_US
dc.identifier.scopus2-s2.0-85021347686en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage37en_US
dc.identifier.urihttps://doi.org/10.15570/actaapa.2017.11
dc.identifier.urihttps://hdl.handle.net/20.500.12491/9399
dc.identifier.volume26en_US
dc.identifier.wosWOS:000405953600003en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorŞereflican, Betül
dc.institutionauthorBuğdaycı, Güler
dc.language.isoenen_US
dc.publisherDermatovenerological Soc Sloveniaen_US
dc.relation.ispartofActa Dermatovenerologica Alpina Pannonica Et Adriaticaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAlternative Complement Pathwayen_US
dc.subjectPsoriasisen_US
dc.subjectChronic Inflammatory Skin Disease
dc.titleComponents of the alternative complement pathway in patients with psoriasisen_US
dc.typeArticleen_US

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