Atherosclerosis assessment and rheumatoid arthritis

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dc.authorid0000-0003-1710-7018en_US
dc.authorid0000-0002-1730-2991
dc.authorid0000-0001-9875-6065
dc.contributor.authorBes, Cemal
dc.contributor.authorGürel, Safiye
dc.contributor.authorBuğdaycı, Güler
dc.contributor.authorDikbaş, Oğuz
dc.contributor.authorSoy, Mehmet
dc.date.accessioned2021-06-23T19:49:46Z
dc.date.available2021-06-23T19:49:46Z
dc.date.issued2018
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractRheumatoid arthritis is associated with increased morbidity and mortality due to atherosclerotic cardiovascular diseases. Lipoprotein-associated phospholipase A2 (Lp-PLA2) is an enzyme of phospholipase A2; it plays an important role in inflammation and atherosclerosis. Herein we aimed to investigate whether Lp-PLA2 activity is associated with atherosclerosis in patients with rheumatoid arthritis and compare the Lp-PLA2 activity with carotid intima media thickness (CIMT). 25 patients with rheumatoid arthritis and 40 controls (20 patients with type 2 diabetes mellitus [DM] and 20 healthy controls) were included in the study. Frozen serum samples were used for analyzing Lp-PLA2 activity. Disease activity was calculated with DAS28 (Disease Activity Score 28) in the rheumatoid arthritis group. The mean CIMT was calculated in all participants. Lp-PLA2 activity was significantly higher in the DM group (p = 0.006) and LDL (Low density cholesterol levels) were lower in rheumatoid arthritis and healthy control groups compared with diabetics (p = 0.001 and p = 0.029, respectively). The mean CIMT was significantly higher in patients with type 2 DM (p = 0.047). Lp-PLA2 activity was not increased in the rheumatoid arthritis group when compared with healthy controls and the DM group. This result may be associated with low disease activity scores in patients with rheumatoid arthritis.en_US
dc.identifier.doi10.1007/s00393-016-0239-3
dc.identifier.endpage334en_US
dc.identifier.issn0340-1855
dc.identifier.issn1435-1250
dc.identifier.issue4en_US
dc.identifier.pmid27913876en_US
dc.identifier.scopus2-s2.0-85000978464en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage330en_US
dc.identifier.urihttps://doi.org/10.1007/s00393-016-0239-3
dc.identifier.urihttps://hdl.handle.net/20.500.12491/9610
dc.identifier.volume77en_US
dc.identifier.wosWOS:000431408700011en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorBes, Cemal
dc.institutionauthorBuğdaycı, Güler
dc.institutionauthorGürel, Safiye
dc.institutionauthorDikbaş, Oğuz
dc.institutionauthorSoy, Mehmet
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofZeitschrift Fur Rheumatologieen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDisease activityen_US
dc.subjectAtherosclerosisen_US
dc.subjectArthritisen_US
dc.subjectGlucoseen_US
dc.subjectHealthyen_US
dc.titleAtherosclerosis assessment and rheumatoid arthritisen_US
dc.typeArticleen_US

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