Mechanisms of glybenclamide-mediated anti-arrhythmia and ischemic conditionining in a rat model of myocardial infarction: Role of yohimbine treatment

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dc.authorid0000-0001-5073-0691
dc.authorid0000-0002-7527-4634
dc.authorid0000-0003-1730-6463
dc.contributor.authorBozdoğan, Ömer
dc.contributor.authorGonca, Ersöz
dc.contributor.authorSuveren, Eylem
dc.contributor.authorGökçe, Fatih
dc.date.accessioned2021-06-23T18:40:22Z
dc.date.available2021-06-23T18:40:22Z
dc.date.issued2004
dc.departmentBAİBÜ, Fen Edebiyat Fakültesi, Biyoloji Bölümüen_US
dc.departmentBAİBÜ, Lisansüstü Eğitim Enstitüsü, Fen Bilimleri, Biyoloji Ana Bilim Dalı
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
dc.description.abstractGlibenclamide (Glyburide), a widely used second-generation sulfonylurea hypoglycemic agent, is a known specific blocker of adenosine triphosphate (ATP) sensitive potassium (K+) channels. Although the blockage of the ATP dependent potassium channel reduces arrhythmia, it increases enfarct size. Yohimbine is an alpha-2 blocker that reduces infarct size as suggested by several studies. We hypothesized that a combination of yohimbine and glibenclamide may be more effective in reducing the arrhythmia following ligation. The arteria descendence (LAD) branch of the left coronary artery in conscious rats was ligated and arrhythmia was recorded during the 15 min following coronary ligation. Sixteen hours after coronary ligation, infarcted myocardium was determined by histological analysis. One and five mg/kg of yohimbine and 5mg/kg of glibenclamide were given intraperitoneally 25 min before ligation. Yohimbine in a 5 mg/kg dosage reduced both the occurrence and the duration of ventricular fibrillation (VF) and ventricular tachycardia. The combination of yohimbine and glibenclamide did not exhibit any additive or synergistic effects on the antiarrhythmic effect of each drug alone following coronary ligation. Moreover, yohimbine in 5mg/kg doses and a combination of 1 mg/kg of yohimbine and glibenclamide increased the survival rate after coronary ligation compared to the non-treated group. The combination of glybenclamide with yohimbine had no clear additive effects such as reducing arrhythmia following cooronary ligation. The antiarrhythmia produced by glibenclamide may not only depend on the blockage of the ATP dependent potassium channels, but also on adrenergic preconditioning.en_US
dc.identifier.endpage27en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage21en_US
dc.identifier.trdizinid53703en_US
dc.identifier.urihttps://app.trdizin.gov.tr/makale/TlRNM01ETXo
dc.identifier.urihttps://hdl.handle.net/20.500.12491/3080
dc.identifier.volume34en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.institutionauthorBozdoğan, Ömer
dc.institutionauthorGonca, Ersöz
dc.institutionauthorSuveren, Eylem
dc.institutionauthorGökçe, Fatih
dc.language.isoenen_US
dc.relation.ispartofTurkish Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectATP Sensitive Potassium Channelsen_US
dc.subjectHypoglycemic Sulfonylurea Compounds
dc.subjectMyocardial İschemia
dc.subjectArrhythmia
dc.subjectYohimbine
dc.subjectATP Duyarlı Potasyum Kanalları
dc.subjectHipoglisemik Sülfonilüre Bileşikleri
dc.subjectMiyokardiyal İskemi
dc.subjectAritmi
dc.subjectYohimbin
dc.titleMechanisms of glybenclamide-mediated anti-arrhythmia and ischemic conditionining in a rat model of myocardial infarction: Role of yohimbine treatmenten_US
dc.typeArticleen_US

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