Mechanisms of glybenclamide-mediated anti-arrhythmia and ischemic conditionining in a rat model of myocardial infarction: Role of yohimbine treatment
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Dosyalar
Tarih
2004
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Glibenclamide (Glyburide), a widely used second-generation sulfonylurea hypoglycemic agent, is a known specific blocker of adenosine triphosphate (ATP) sensitive potassium (K+) channels. Although the blockage of the ATP dependent potassium channel reduces arrhythmia, it increases enfarct size. Yohimbine is an alpha-2 blocker that reduces infarct size as suggested by several studies. We hypothesized that a combination of yohimbine and glibenclamide may be more effective in reducing the arrhythmia following ligation. The arteria descendence (LAD) branch of the left coronary artery in conscious rats was ligated and arrhythmia was recorded during the 15 min following coronary ligation. Sixteen hours after coronary ligation, infarcted myocardium was determined by histological analysis. One and five mg/kg of yohimbine and 5mg/kg of glibenclamide were given intraperitoneally 25 min before ligation. Yohimbine in a 5 mg/kg dosage reduced both the occurrence and the duration of ventricular fibrillation (VF) and ventricular tachycardia. The combination of yohimbine and glibenclamide did not exhibit any additive or synergistic effects on the antiarrhythmic effect of each drug alone following coronary ligation. Moreover, yohimbine in 5mg/kg doses and a combination of 1 mg/kg of yohimbine and glibenclamide increased the survival rate after coronary ligation compared to the non-treated group. The combination of glybenclamide with yohimbine had no clear additive effects such as reducing arrhythmia following cooronary ligation. The antiarrhythmia produced by glibenclamide may not only depend on the blockage of the ATP dependent potassium channels, but also on adrenergic preconditioning.
Açıklama
Anahtar Kelimeler
ATP Sensitive Potassium Channels, Hypoglycemic Sulfonylurea Compounds, Myocardial İschemia, Arrhythmia, Yohimbine, ATP Duyarlı Potasyum Kanalları, Hipoglisemik Sülfonilüre Bileşikleri, Miyokardiyal İskemi, Aritmi, Yohimbin
Kaynak
Turkish Journal of Medical Sciences
WoS Q Değeri
Scopus Q Değeri
Q3
Cilt
34
Sayı
1
