Abelmoschus esculentus (L.) Moench seed extract alleviates acute acetaminophen induced liver damage in rats

Basit Öğe Kaydı
dc.authorid0000-0003-2469-9509en_US
dc.authorid0000-0002-8212-7149en_US
dc.authorid0000-0001-6768-1275en_US
dc.authorid0000-0003-0434-3206en_US
dc.authorid0000-0001-9865-1685en_US
dc.contributor.authorKocabey, Hüseyin
dc.contributor.authorBekdaş, Mervan
dc.contributor.authorÇetinkaya, Ayhan
dc.contributor.authorDüzcü, Selma Erdoğan
dc.contributor.authorAlışık, Murat
dc.contributor.authorTürel, İdris
dc.date.accessioned2024-05-07T12:25:35Z
dc.date.available2024-05-07T12:25:35Z
dc.date.issued2023en_US
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionThe authors thank Dr. Arzu Birinci Y & imath;ld & imath;r & imath;m for preparing Abelmoschus esculentus seed extract. This research was supported by the scientific research fund from the Abant Izzet Baysal University (2020.08.23.1469).en_US
dc.description.abstractAcetaminophen (N-acetyl-p-aminophenol, APAP), commonly called the 'paracetamol', is one of the most regularly utilized medicines, particularly in children. When administered at the recommended doses, it is a safe medication. However, oxidative stress and inflammation caused by exposure to toxic doses lead to centrilobular hepatic necrosis. N-acetylcysteine (NAC) is utilized in the therapy, however it has potential adverse effects. On the other hand, it is known that the seeds of the common vegetable Okra, Abelmoschus esculentus (AE), a herbal product, possess antioxidant and anti-inflammatory qualities. In the present study, we explored whether AE can be used as an alternative to standard NAC therapy without any adverse effect in the treatment of acute APAP induced liver injury. Forty male Wistar rats were placed into five groups: Control, AE, APAP, APAP+AE and APAP+AE+NAC groups. Antioxidants such as native thiol and total thiol were found rised in the APAP group by adding AE (p =0.043 and p =0.028, respectively). Anti-inflammatory indicator IL-10 was also found increased, while marker ALT, which is a sign of hepatotoxicity, got decreased (P=0.005 and P <0.001, respectively). Histologically, AE has been shown to improve worsened congestion (P =0.003), cytoplasmic vacuolization (P =0.01), sinusoidal dilatation (P =0.001), Kupffer cell proliferation (P <0.001) and inflammation (P <0.001). These results suggest that the okra seeds may be a potential therapeutic agent for paracetamol induced hepatotoxicity and it can be attributed to the antioxidant and anti-inflammatory properties.en_US
dc.description.sponsorshipAbant Izzet Baysal University [2020.08.23.1469]en_US
dc.identifier.citationKocabey, H., Bekdas, M., Cetinkaya, A., Duzcu, S. E., Alisik, M., Dincel, G. K., & Turel, I. (2023). Abelmoschus esculentus (L.) Moench seed extract alleviates acute acetaminophen induced liver damage in rats.en_US
dc.identifier.doi10.56042/ijeb.v61i11.1326
dc.identifier.endpage860en_US
dc.identifier.issn0019-5189
dc.identifier.issn0975-1009
dc.identifier.issue11en_US
dc.identifier.startpage852en_US
dc.identifier.urihttp://dx.doi.org/10.56042/ijeb.v61i11.1326
dc.identifier.urihttps://hdl.handle.net/20.500.12491/12127
dc.identifier.volume61en_US
dc.identifier.wosWOS:001115798500002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.institutionauthorKocabey, Hüseyin
dc.institutionauthorBekdaş, Mervan
dc.institutionauthorÇetinkaya, Ayhan
dc.institutionauthorDüzcü, Selma Erdoğan
dc.institutionauthorAlışık, Murat
dc.institutionauthorTürel, İdris
dc.language.isoenen_US
dc.publisherNational Institute of Science Communication and Information Resources (NISCAIR)en_US
dc.relation.ispartofIndian Journal of Experimental Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectN-Acetyl Cysteine (NAC)en_US
dc.subjectHepatic Injuryen_US
dc.subjectInterleukin-10en_US
dc.subjectMacrophagesen_US
dc.subjectParacetamolen_US
dc.subjectAntioxidanten_US
dc.titleAbelmoschus esculentus (L.) Moench seed extract alleviates acute acetaminophen induced liver damage in ratsen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
huseyin-kocabey.pdf
Boyut:
3.7 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin/Full Text
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Cerrahi Tıp Bilimleri Bölümü Koleksiyonu
Dahili Tıp Bilimleri Bölümü Koleksiyonu
Temel Tıp Bilimleri Bölümü Koleksiyonu