Abelmoschus esculentus (L.) Moench seed extract alleviates acute acetaminophen induced liver damage in rats

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Küçük Resim

Tarih

2023

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

National Institute of Science Communication and Information Resources (NISCAIR)

Erişim Hakkı

info:eu-repo/semantics/openAccess

Özet

Acetaminophen (N-acetyl-p-aminophenol, APAP), commonly called the 'paracetamol', is one of the most regularly utilized medicines, particularly in children. When administered at the recommended doses, it is a safe medication. However, oxidative stress and inflammation caused by exposure to toxic doses lead to centrilobular hepatic necrosis. N-acetylcysteine (NAC) is utilized in the therapy, however it has potential adverse effects. On the other hand, it is known that the seeds of the common vegetable Okra, Abelmoschus esculentus (AE), a herbal product, possess antioxidant and anti-inflammatory qualities. In the present study, we explored whether AE can be used as an alternative to standard NAC therapy without any adverse effect in the treatment of acute APAP induced liver injury. Forty male Wistar rats were placed into five groups: Control, AE, APAP, APAP+AE and APAP+AE+NAC groups. Antioxidants such as native thiol and total thiol were found rised in the APAP group by adding AE (p =0.043 and p =0.028, respectively). Anti-inflammatory indicator IL-10 was also found increased, while marker ALT, which is a sign of hepatotoxicity, got decreased (P=0.005 and P <0.001, respectively). Histologically, AE has been shown to improve worsened congestion (P =0.003), cytoplasmic vacuolization (P =0.01), sinusoidal dilatation (P =0.001), Kupffer cell proliferation (P <0.001) and inflammation (P <0.001). These results suggest that the okra seeds may be a potential therapeutic agent for paracetamol induced hepatotoxicity and it can be attributed to the antioxidant and anti-inflammatory properties.

Açıklama

The authors thank Dr. Arzu Birinci Y & imath;ld & imath;r & imath;m for preparing Abelmoschus esculentus seed extract. This research was supported by the scientific research fund from the Abant Izzet Baysal University (2020.08.23.1469).

Anahtar Kelimeler

N-Acetyl Cysteine (NAC), Hepatic Injury, Interleukin-10, Macrophages, Paracetamol, Antioxidant

Kaynak

Indian Journal of Experimental Biology

WoS Q Değeri

Q4

Scopus Q Değeri

Cilt

61

Sayı

11

Künye

Kocabey, H., Bekdas, M., Cetinkaya, A., Duzcu, S. E., Alisik, M., Dincel, G. K., & Turel, I. (2023). Abelmoschus esculentus (L.) Moench seed extract alleviates acute acetaminophen induced liver damage in rats.