The importance of laboratory parameters in patients with obstructive sleep apnea syndrome

dc.authorid0000-0002-4641-2866en_US
dc.authorid0000-0002-1845-0902en_US
dc.contributor.authorKurt, Özlem Kar
dc.contributor.authorYıldız, Nebil
dc.date.accessioned2021-06-23T19:34:33Z
dc.date.available2021-06-23T19:34:33Z
dc.date.issued2013
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractPlatelet activation and inflammation are the related mechanisms of pathogenesis in obstructive sleep apnea syndrome (OSAS). Mean platelet volume (MPV) and platelet distribution width (PDW) are the markers of platelet activation. C-reactive protein (CRP) and red cell distribution width (RDW) in relation to the inflammation in OSAS might be increased. We aimed to investigate the correlation of the MPV, PDW, and RDW levels with the severity of OSAS. We included 98 patients with suspected OSAS, evaluated by polysomnography. According to their apnea-hypopnea index (AHI), patients were divided into group A (n = 20; 20.4%) with AHI below 5/h; group B (n = 15; 15.3%) with AHI 5 - 14.9/h; group C (n = 26; 26.5%) with AHI 15 - 29.9/h; and group D (n = 37; 37.8%) with AHI >= 30/h. Hemoglobin, MPV, PDW, and RDW were measured using an automated blood cell counter. BMI and age showed a statistically significant and gradual increase in AHI groups. Hemoglobin, platelet, CRP, MPV, and RDW values did not differ between AHI groups. PDW was significantly higher in group D (mean value 14.4 +/- 1.8) than in group A (13.2 +/- 0.5) (P< 0.001). Epworth sleepiness scale was significantly higher in group D (9.9 +/- 5.5) than in group A (5.6 +/- 3.5), B (9.2 +/- 3.6) and C (6.6 +/- 3.8) (P = 0.005). When the four groups were compared, group D had the lowest minimum SpO(2) value [group A (89.4 +/- 3.0), B (86.7 +/- 4.2), C (81.2 +/- 6.4), and D (68.2 +/- 13.0)]. There was a statistically significant correlation between AHI and age (r = 0.35, P< 0.001), BMI (r = 0.31, P = 0.003), PDW (r = 0.28, P = 0.006), and Epworth sleepiness scale (r = 0.29, P = 0.007). However, AHI was not correlated with CRP, MPV, and RDW. PDW is higher in severe OSAS and is correlated with different parameters of breathing function during sleep. The severity of OSAS was not correlated with CRP, MPV, and RDW. These findings show an evidence for platelet activation in OSAS and suggest that PDW might be related markers of OSAS severity. (c) 2013 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.en_US
dc.identifier.doi10.1097/MBC.0b013e32835d53d4
dc.identifier.endpage374en_US
dc.identifier.issn0957-5235
dc.identifier.issn1473-5733
dc.identifier.issue4en_US
dc.identifier.pmid23322273en_US
dc.identifier.scopus2-s2.0-84877705989en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage371en_US
dc.identifier.urihttps://doi.org/10.1097/MBC.0b013e32835d53d4
dc.identifier.urihttps://hdl.handle.net/20.500.12491/7550
dc.identifier.volume24en_US
dc.identifier.wosWOS:000318784200004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKurt, Özlem Kar
dc.institutionauthorYıldız, Nebil
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofBlood Coagulation & Fibrinolysisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMean Platelet Volumeen_US
dc.subjectObstructive Sleep Apnea Syndromeen_US
dc.subjectPlatelet Distribution Widthen_US
dc.subjectRed Cell Distribution Widthen_US
dc.titleThe importance of laboratory parameters in patients with obstructive sleep apnea syndromeen_US
dc.typeArticleen_US

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