The importance of laboratory parameters in patients with obstructive sleep apnea syndrome
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Tarih
2013
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Lippincott Williams & Wilkins
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Platelet activation and inflammation are the related mechanisms of pathogenesis in obstructive sleep apnea syndrome (OSAS). Mean platelet volume (MPV) and platelet distribution width (PDW) are the markers of platelet activation. C-reactive protein (CRP) and red cell distribution width (RDW) in relation to the inflammation in OSAS might be increased. We aimed to investigate the correlation of the MPV, PDW, and RDW levels with the severity of OSAS. We included 98 patients with suspected OSAS, evaluated by polysomnography. According to their apnea-hypopnea index (AHI), patients were divided into group A (n = 20; 20.4%) with AHI below 5/h; group B (n = 15; 15.3%) with AHI 5 - 14.9/h; group C (n = 26; 26.5%) with AHI 15 - 29.9/h; and group D (n = 37; 37.8%) with AHI >= 30/h. Hemoglobin, MPV, PDW, and RDW were measured using an automated blood cell counter. BMI and age showed a statistically significant and gradual increase in AHI groups. Hemoglobin, platelet, CRP, MPV, and RDW values did not differ between AHI groups. PDW was significantly higher in group D (mean value 14.4 +/- 1.8) than in group A (13.2 +/- 0.5) (P< 0.001). Epworth sleepiness scale was significantly higher in group D (9.9 +/- 5.5) than in group A (5.6 +/- 3.5), B (9.2 +/- 3.6) and C (6.6 +/- 3.8) (P = 0.005). When the four groups were compared, group D had the lowest minimum SpO(2) value [group A (89.4 +/- 3.0), B (86.7 +/- 4.2), C (81.2 +/- 6.4), and D (68.2 +/- 13.0)]. There was a statistically significant correlation between AHI and age (r = 0.35, P< 0.001), BMI (r = 0.31, P = 0.003), PDW (r = 0.28, P = 0.006), and Epworth sleepiness scale (r = 0.29, P = 0.007). However, AHI was not correlated with CRP, MPV, and RDW. PDW is higher in severe OSAS and is correlated with different parameters of breathing function during sleep. The severity of OSAS was not correlated with CRP, MPV, and RDW. These findings show an evidence for platelet activation in OSAS and suggest that PDW might be related markers of OSAS severity. (c) 2013 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
Açıklama
Anahtar Kelimeler
Mean Platelet Volume, Obstructive Sleep Apnea Syndrome, Platelet Distribution Width, Red Cell Distribution Width
Kaynak
Blood Coagulation & Fibrinolysis
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
24
Sayı
4
