Could artesunate have a positive effect on the neurological complications related to infection when it is used in the treatment of covid-19?

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dc.authorid0000-0001-8616-832X
dc.authorid0000-0002-5099-5128
dc.contributor.authorUzun, Tuğçenur
dc.contributor.authorToptaş, Orçun
dc.contributor.authorTürkoğlu, Şule Aydın
dc.date.accessioned2021-06-23T19:53:46Z
dc.date.available2021-06-23T19:53:46Z
dc.date.issued2020
dc.departmentBAİBÜ, Diş Hekimliği Fakültesi, Ağız Diş ve Çene Cerrahisi Ana Bilim Dalıen_US
dc.description.abstractArtesunate is a safe noncytotoxic drug with low side effects which is used in the treatment of chloroquine-resistant malaria. In addition to being an antimalarial drug, artesunate also has immunomodulatory, anticarcinogenic, and antiviral activity. There are in vivo and in vitro studies reporting that artesunate may have a positive effect on the treatment of COVID-19. Artesunate may be effective based on its effect on the anti-inflammatory activity, chloroquine-like endocytosis inhibition mechanism, and nuclear factor kappa B (NF-kappa B) signal pathway. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may cause neurological complications in addition to targeting the respiratory system. In this study, we have discussed the possible neuroprotective action mechanisms of artesunate. We think that systemic and intranasal topical artesunate administration may have a positive effect on neurological complications resulting from COVID-19.en_US
dc.identifier.doi10.1021/acschemneuro.0c00601
dc.identifier.endpage4006en_US
dc.identifier.issn1948-7193
dc.identifier.issue24en_US
dc.identifier.pmid33269910en_US
dc.identifier.scopus2-s2.0-85097744416en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage4001en_US
dc.identifier.urihttps://doi.org/10.1021/acschemneuro.0c00601
dc.identifier.urihttps://hdl.handle.net/20.500.12491/10240
dc.identifier.volume11en_US
dc.identifier.wosWOS:000600203100004en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorTürkoğlu, Şule Aydın
dc.institutionauthorToptaş, Orçun
dc.language.isoenen_US
dc.publisherAmer Chemical Socen_US
dc.relation.ispartofAcs Chemical Neuroscienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCOVID-19en_US
dc.subjectArtesunateen_US
dc.subjectNeurologicalen_US
dc.subjectIntranasalen_US
dc.subjectGuillain-Barreen_US
dc.subjectNF-kappa Ben_US
dc.subjectThrombocytosisen_US
dc.titleCould artesunate have a positive effect on the neurological complications related to infection when it is used in the treatment of covid-19?en_US
dc.typeArticleen_US

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