The effects of vasoactive intestinal peptide on duramater nitric oxide levels and vessel-contraction responses at sympathectomized rats

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dc.authorid0000-0001-5912-9392
dc.authorid0000-0003-1410-740X
dc.contributor.authorTöre, Fatma
dc.contributor.authorKorkmaz, Orhan Tansel
dc.contributor.authorDoğrukol-Ak, Dilek
dc.contributor.authorTunçel, Neşe
dc.date.accessioned2021-06-23T19:26:07Z
dc.date.available2021-06-23T19:26:07Z
dc.date.issued2009
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.descriptionJoint Meeting of the European-Neuropeptides-Club/Summer Neuropeptides Conference -- JUL 20-23, 2009 -- Salzburg, AUSTRIAen_US
dc.description.abstractNitric oxide (NO) and neurogenic inflammation in dura mater due to nociceptor activation has been implicated for pathophysiology of primary headache disorders. Development of migraine has also been observed in patients treated with ganglion blockage for sympathetic reflex dystrophy. Vasoactive intestinal peptide (VIP) is an antioxidant, antiinflammatory, and neuroprotective neuropeptide. This study is intended to investigate the effects of VIP on dura mater NO levels and vessel-contraction responses in sympathectomized rats. In the experiments, 30 male rats in five groups were used. Group 1 sympathectomized: under anesthesia, superior cervical sympathetic ganglion was removed via incision at the center line in the neck area. Group 2 sympathectomized+ VIP: postoperative VIP of 25 ng/kg/day (0.2 ml) intraperitoneally administered to the rats exposed to the same operations for 5 days. Group 3 sham: ganglia and nerves were exposed but not dissected. Group 4 control: no treatment was done. Group 5 VIP: only VIP was administered for 5 days. Sympathectomy induced a significant increase in dura mater NO levels and VIP decreased NO to control levels and increased the norepinephrine vesselcontraction responses of sympathectomized rats. VIP is an efficient NO modulator in superior cervical ganglionectomized rats.en_US
dc.description.sponsorshipEuropean Neuropeptides Cluben_US
dc.identifier.doi10.1007/s12031-009-9310-8
dc.identifier.endpage414en_US
dc.identifier.issn0143-4179
dc.identifier.issue5en_US
dc.identifier.pmid19936638en_US
dc.identifier.scopus2-s2.0-77951621531en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage413en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12491/6419
dc.identifier.urihttps://link.springer.com/article/10.1007/s12031-009-9310-8
dc.identifier.volume43en_US
dc.identifier.wosWOS:000271890700020en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorTöre, Fatma
dc.language.isoenen_US
dc.publisherChurchill Livingstoneen_US
dc.relation.ispartofNeuropeptidesen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMigraineen_US
dc.subjectVasoactive Intestinal Peptide
dc.subjectDura Mater
dc.subjectNitric Oxide
dc.titleThe effects of vasoactive intestinal peptide on duramater nitric oxide levels and vessel-contraction responses at sympathectomized ratsen_US
dc.typeConference Objecten_US

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