The effects of vasoactive intestinal peptide on duramater nitric oxide levels and vessel-contraction responses at sympathectomized rats
Yükleniyor...
Dosyalar
Tarih
2009
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Churchill Livingstone
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Nitric oxide (NO) and neurogenic inflammation in
dura mater due to nociceptor activation has been implicated
for pathophysiology of primary headache disorders. Development of migraine has also been observed in patients treated
with ganglion blockage for sympathetic reflex dystrophy.
Vasoactive intestinal peptide (VIP) is an antioxidant, antiinflammatory, and neuroprotective neuropeptide. This study is
intended to investigate the effects of VIP on dura mater NO
levels and vessel-contraction responses in sympathectomized
rats. In the experiments, 30 male rats in five groups were used.
Group 1 sympathectomized: under anesthesia, superior
cervical sympathetic ganglion was removed via incision at
the center line in the neck area. Group 2 sympathectomized+
VIP: postoperative VIP of 25 ng/kg/day (0.2 ml) intraperitoneally administered to the rats exposed to the same
operations for 5 days. Group 3 sham: ganglia and nerves
were exposed but not dissected. Group 4 control: no
treatment was done. Group 5 VIP: only VIP was administered for 5 days. Sympathectomy induced a significant
increase in dura mater NO levels and VIP decreased NO to
control levels and increased the norepinephrine vesselcontraction responses of sympathectomized rats. VIP is an
efficient NO modulator in superior cervical ganglionectomized rats.
Açıklama
Joint Meeting of the European-Neuropeptides-Club/Summer Neuropeptides Conference -- JUL 20-23, 2009 -- Salzburg, AUSTRIA
Anahtar Kelimeler
Migraine, Vasoactive Intestinal Peptide, Dura Mater, Nitric Oxide
Kaynak
Neuropeptides
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
43
Sayı
5
