Carbon dioxide insufflation causes upper urinary tract injury in the early period of an experimental vesicoureteral reflux model

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dc.authorid0000-0003-1719-4924
dc.contributor.authorKılınçaslan, Hüseyin
dc.contributor.authorGündoğdu, Gökhan
dc.contributor.authorTerzi, Elçin Hakan
dc.contributor.authorÖztürk, Hülya
dc.contributor.authorFırat, Tülin
dc.contributor.authorTosun, Mehmet
dc.date.accessioned2021-06-23T19:34:06Z
dc.date.available2021-06-23T19:34:06Z
dc.date.issued2013
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractUreteral reimplantation via pneumovesicum is a new aspect of vesicoureteral reflux management. We aimed to determine the effects of carbon dioxide (CO2) insufflation on the upper urinary tract in an experimental model. Thirty New Zealand rabbits were allocated into five groups of six rabbits each. Right ureters were cannulated for CO2 insufflation in four groups. The pressures and durations of CO2 insufflation in the respective groups were as follows: Group A (10 mm Hg, 2 h); B (12 mm Hg, 2 h); C (10 mm Hg, 4 h); and D (12 mm Hg, 4 h) and control (E). Blood gas analysis, urea and creatinine levels were measured from renal veins and aorta. Histopathological evaluation of the renal parenchyma and ureters was scored. Significant histopathological changes were detected in the ipsilateral ureter and renal parenchyma exposed to CO2 insufflation, predominantly observed in groups insufflated for longer durations, p < 0.05. Blood gases drawn separately from renal veins were significantly more acidotic, and serum urea and creatinine levels were increased in all the groups, p < 0.05. CO2 causes significant histopathological and biochemical changes in the early period. Long-term results are required to determine whether permanent renal injury occurs.en_US
dc.identifier.doi10.1007/s00383-013-3410-9
dc.identifier.endpage1320en_US
dc.identifier.issn0179-0358
dc.identifier.issn1437-9813
dc.identifier.issue12en_US
dc.identifier.pmid24005825en_US
dc.identifier.scopus2-s2.0-84890538296en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1311en_US
dc.identifier.urihttps://doi.org/10.1007/s00383-013-3410-9
dc.identifier.urihttps://hdl.handle.net/20.500.12491/7381
dc.identifier.volume29en_US
dc.identifier.wosWOS:000327466200013en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorTerzi, Elçin Hakan
dc.institutionauthorÖztürk, Hülya
dc.institutionauthorFırat, Tülin
dc.institutionauthorTosun, Mehmet
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofPediatric Surgery Internationalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCarbon dioxideen_US
dc.subjectUpper Urinary Tracten_US
dc.subjectVesicoureteral Refluxen_US
dc.subjectPneumovesicumen_US
dc.subjectUreteral Reimplantationen_US
dc.titleCarbon dioxide insufflation causes upper urinary tract injury in the early period of an experimental vesicoureteral reflux modelen_US
dc.typeArticleen_US

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