Efficacy of moxifloxacin compared to teicoplanin in the treatment of implant-related chronic osteomyelitis in rats

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dc.authorid0000-0002-2860-1794
dc.authorid0000-0003-2153-7774
dc.contributor.authorÖzturan, Kutay Engin
dc.contributor.authorYücel, İstemi
dc.contributor.authorKoçoğlu, Esra
dc.contributor.authorÇakıcı, Hüsamettin
dc.contributor.authorGüven, Melih
dc.date.accessioned2021-06-23T19:26:48Z
dc.date.available2021-06-23T19:26:48Z
dc.date.issued2010
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractTreatment of implant-related chronic osteomyelitis is often difficult and usually consists of implant removal, extensive surgical debridement, and prolonged antibiotic use This study was performed to assess the efficacy of moxifloxacin compared to a glycopeptide, teicoplanin in chronic implant-related methicillin-sensitive Staphylococcus aureus (MSSA) osteomyelitis The left femoral medullar cavities of 60 Wistar male rats were contaminated with 100 mu l of 10(8) cfu/ml methicillin-sensitive S aureus (ATCC 29213) and Kirschner wires were placed into the medulla of the femur Alter 6 weeks, rats were randomly divided into five groups In two groups, the Kirschner wires were removed Experimental groups were as follows group 1 contaminated, Kirschner wire inside, received teicoplamn, group 2 contaminated, Kirschner wire removed, received teicoplanin, group 3 contaminated, Kirschner wire inside, received moxifloxacm; group 4 contaminated, Kirschner wire removed, received moxifloxacm, group 5 contaminated, Kirschner wire inside, no antibiotics (control group) Groups 1 and 2 received teicoplanin (20 mg/kg once daily), whereas groups 3 and 4 received moxifloxacin (10 mg/kg twice daily) intraperitoneally for 28 days At the end of the treatment, animals were sacrificed by inhalation anesthesia with ether and femora were retrieved and bacterial counts (cfu/g) were determined Bacterial counts in all study groups were significantly reduced relative to the control The decrease of bacterial counts was more prominent in group 4 compared to group 1 (p = 0 001) and group 2 = 0 003) Moxifloxacin therapy is an effective alternative to teicoplamn for chronic implant-related MSSA osteomyelitis (C) 2010 Orthopaedic Research Society Published by Wiley Periodicals, Inc J Orthop Res 28 1368-1372, 2010en_US
dc.identifier.doi10.1002/jor.21159
dc.identifier.endpage1372en_US
dc.identifier.issn0736-0266
dc.identifier.issn1554-527X
dc.identifier.issue10en_US
dc.identifier.pmid20839321en_US
dc.identifier.scopus2-s2.0-77957190911en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1368en_US
dc.identifier.urihttps://doi.org/10.1002/jor.21159
dc.identifier.urihttps://hdl.handle.net/20.500.12491/6654
dc.identifier.volume28en_US
dc.identifier.wosWOS:000281657200015en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorÖzturan, Kutay Engin
dc.institutionauthorKoçoğlu, Esra
dc.institutionauthorÇakıcı, Hüsamettin
dc.institutionauthorGüven, Melih
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal Of Orthopaedic Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMoxifloxacinen_US
dc.subjectTeicoplaninen_US
dc.subjectImplant-related Chronic Osteomyelitisen_US
dc.subjectStaphylococcus Aureusen_US
dc.titleEfficacy of moxifloxacin compared to teicoplanin in the treatment of implant-related chronic osteomyelitis in ratsen_US
dc.typeArticleen_US

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