In vitro activity of sodium-benzoate against isolates of methicillin-resistant staphylococcus aureus

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dc.authorid0000-0003-1514-1685en_US
dc.authorid0000-0001-6203-5039en_US
dc.contributor.authorKarabay, Oğuz
dc.contributor.authorŞahin, İdris
dc.date.accessioned2021-06-23T19:18:33Z
dc.date.available2021-06-23T19:18:33Z
dc.date.issued2005
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
dc.description.abstractBackground. Worldwide, methicillin-resistant Staphylococcus aureus (MRSA) rates have increased dramatically during the last decades. Sodium benzoate (SB) is a chemical substance that is used for preparing food and drinks and in the treatment of some metabolic (urea cycle disorders and hepatic coma) diseases. No studies were found which focussed on the effects of SB in MRSA infections. The aim was to determine in vitro activity of sodium benzoate against MRSA clinical isolates. Methods: In this study, MIC for SB in 36 MRSA and 29 methicillin-sensitive Staphylococcus aureus (MSSA) isolates were determined by a broth microdilution method recommended by the National Committee for Clinical Laboratory Standards. Results: The MIC at which all of the MRSA and MSSA strains were inhibited was at 32 mu g/ml and higher concentrations. Conclusion: Sodium benzoate showed good in vitro activity against clinically relevant MRSA and MSSA isolates. It is suggested in this study that this cheap substance, which has been used for systemic and local treatment of infection in humans, may be used alternatively for the treatment of MRSA infections. However it is clear that more comprehensive and in vivo studies are needed to further elucidate the activity of SB against MRSA infections.en_US
dc.identifier.endpage109en_US
dc.identifier.issn0043-3144
dc.identifier.issn2309-5830
dc.identifier.issue2en_US
dc.identifier.pmid15999879en_US
dc.identifier.scopus2-s2.0-21044442852en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage107en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12491/5755
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-21044442852&doi=10.1590%2fS0043-31442005000200004&partnerID=40&md5=1764005813f810ace5bae4b7a2
dc.identifier.volume54en_US
dc.identifier.wosWOS:000230097300004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKarabay, Oğuz
dc.institutionauthorŞahin, İdris
dc.language.isoenen_US
dc.publisherUniv West Indies Faculty Medical Sciencesen_US
dc.relation.ispartofWest Indian Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectStaphylococcus Aureusen_US
dc.subjectSodium Benzoate
dc.subjectIsolates
dc.subjectVitro Activity
dc.titleIn vitro activity of sodium-benzoate against isolates of methicillin-resistant staphylococcus aureusen_US
dc.typeArticleen_US

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