Effects of iohexol on ventilatory functions in patients undergoing diagnostic coronary angiography
Yükleniyor...
Dosyalar
Tarih
2004
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background and objectives Adverse respiratory reactions have been reported with intravascular radiographic contrast media. The aim of the present study is to assess the effects of iohexol on pulmonary functions in patients undergoing diagnostic coronary angiography (CA). Materials and methods: 30 patients enrolled in the study. The respiratory functions of the patients were measured at three different stages during angiography (before, immediately after and 2 h later) and arterial blood gas analyses were performed at six stages during CA (before, immediately after the insertion of angiography catheter, 2 min after the injection of contrast agent, at the end of angiography, an hour and 2 h after angiography). A single, experienced angiographer performed the angiography procedures via radial artery route. Totally six multiple angled views of the left and right coronary arteries were recorded in all patients by hand injection. None of the patients were performed ventriculography. Results: Angiography caused significant reduction in forced expiratory volume in 1 sec [FEV1] (from 103 15 to 95 17, p < 0.01), forced vital capacity [FVC] (from 99 13 to 95 18, p < 0.05) and maximum mid-expiratory flow rate [MMF] (from 95 33 to 84 29, p < 0.01) whereas there were no significant changes in the mean FEV1/FVC ratios at different stages of angiography. Statistically significant decrease in PaO2 (from 91 10 to 85 13 mmHg, p < 0.01) and arterial O2 saturation (from 97 1% to 96 1%, p < 0.01) were also observed. Data in present study showed a clinically insignificant but statistically significant restrictive impairment in pulmonary functions. Conclusions: Diagnostic CA using iohexol decreases ventilatory functions in a small but significant extent in patients without any overt pulmonary disease.
Açıklama
Anahtar Kelimeler
Coronary Angiography, Iohexol, Ventilatory Function
Kaynak
International Journal Of Cardiovascular Imaging
WoS Q Değeri
Q4
Scopus Q Değeri
Q2
Cilt
20
Sayı
6
