The effects of certain TRP channels and voltage-gated KCNQ/Kv7 channel opener retigabine on calcitonin gene-related peptide release in the trigeminovascular system

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dc.authorid0000-0001-9261-2634en_US
dc.authorid0000-0001-7035-3336en_US
dc.authorid0000-0003-3752-0846en_US
dc.authorid0000-0002-1668-7850en_US
dc.authorid0000-0002-9265-1008en_US
dc.contributor.authorÇıtak, Arzu
dc.contributor.authorKılınç, Erkan
dc.contributor.authorTorun, İbrahim Ethem
dc.contributor.authorAnkaralı, Seyit
dc.contributor.authorDağıstan, Yaşar
dc.contributor.authorYoldaş, Hamit
dc.date.accessioned2023-08-31T08:24:50Z
dc.date.available2023-08-31T08:24:50Z
dc.date.issued2022en_US
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.descriptionBolu Abant Izzet Baysal University Scientific Research Funden_US
dc.description.abstractBackground Calcitonin gene-related peptide release in trigeminovascular system is a pivotal component of neurogenic inflammation underlying migraine pathophysiology. Transient receptor potential channels and voltage-gated KCNQ/Kv7 potassium channels expressed throughout trigeminovascular system are important targets for modulation of calcitonin gene-related peptide release. We investigated the effects of certain transient receptor potential (TRP) channels the vanilloid 1 and 4 (TRPV1 and TRPV4), the ankyrin 1 (TRPA1), and metastatin type 8 (TRPM8), and voltage-gated potassium channel (Kv7) opener retigabine on calcitonin gene-related peptide release from peripheral (dura mater and trigeminal ganglion) and central (trigeminal nucleus caudalis) trigeminal components of rats. Methods The experiments were carried out using well-established in-vitro preparations (hemiskull, trigeminal ganglion and trigeminal nucleus caudalis) from male Wistar rats. Agonists and antagonists of TRPV1, TRPV4, TRPA1 and TRPM8 channels, and also retigabine were tested on the in-vitro release of calcitonin gene-related peptide. Calcitonin gene-related peptide concentrations were measured using enzyme-linked immunosorbent assay. Results Agonists of these transient receptor potential channels induced calcitonin gene-related peptide release from hemiskull, trigeminal ganglion and trigeminal nucleus caudalis, respectively. The transient receptor potential channels-induced calcitonin gene-related peptide releases were blocked by their specific antagonists and reduced by retigabine. Retigabine also decreased basal calcitonin gene-related peptide releases in all preparations. Conclusion Our findings suggest that favorable antagonists of these transient receptor potential channels, or Kv7 channel opener retigabine may be effective in migraine therapy by inhibiting neurogenic inflammation that requires calcitonin gene-related peptide release.en_US
dc.description.sponsorshipBolu Abant Izzet Baysal University Scientific Research Fund [2017.08.02.1212]en_US
dc.identifier.citationCitak, A., Kilinc, E., Torun, I. E., Ankarali, S., Dagistan, Y., & Yoldas, H. (2022). The effects of certain TRP channels and voltage-gated KCNQ/Kv7 channel opener retigabine on calcitonin gene-related peptide release in the trigeminovascular system. Cephalalgia, 42(13), 1375-1386.en_US
dc.identifier.doi10.1177/03331024221114773
dc.identifier.endpage1386en_US
dc.identifier.issn0333-1024
dc.identifier.issn1468-2982
dc.identifier.issue13en_US
dc.identifier.pmid35861239en_US
dc.identifier.scopus2-s2.0-85135033671en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1375en_US
dc.identifier.urihttp://dx.doi.org/10.1177/03331024221114773
dc.identifier.urihttps://hdl.handle.net/20.500.12491/11623
dc.identifier.volume42en_US
dc.identifier.wosWOS:000828847400001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKılınç, Erkan
dc.institutionauthorTorun, İbrahim Ethem
dc.institutionauthorDağıstan, Yaşar
dc.institutionauthorYoldaş, Hamit
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofCephalalgiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMigraineen_US
dc.subjectTrigeminovascular Systemen_US
dc.subjectCGRPen_US
dc.subjectTransient Receptor Potential Channelsen_US
dc.subjectVoltage-Gated KCNQen_US
dc.subjectKv7 Potassium Channelsen_US
dc.titleThe effects of certain TRP channels and voltage-gated KCNQ/Kv7 channel opener retigabine on calcitonin gene-related peptide release in the trigeminovascular systemen_US
dc.typeArticleen_US

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